31P-MAGNETIC RESONANCE SPECTROSCOPY IN EVALUATING HEPATIC FUNCTION : A POSSIBLE APPLICATION IN DONOR ASSESSMENT IN DONOR ASSESSMENT PRIOR TO LIVER TRANSPLANTATION

31P 磁共振波谱法评估肝功能：在肝移植前供体评估中的可能应用

• 批准号: 07457249
• 负责人: KAWASAKI Seiji
• 金额: $ 3.52万
• 依托单位: SHINSHU UNIVERSITY,SCHOOL OF MEEDICINE
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07457249/
• 关键词: LIVER TRANSPLANTATION; GRAFT VIABILITY; 生体部分肝移植; 核磁気共鳴; 31P-MRS

MAGNETIC RESONANCE SPECTROSCOPY (MRS) IS A NONINVASIVE METHOD OF MEASURING THE CONCENTRATION OF CHEMICAL SUBSTANCES IN VIVO.31P-MRS HAS BEEN USED TO ASSESS THE VIABILITY OF ISOLATED ORGANS IN SMALL ANIMALS.SIZE CONSTRAINTS HAVE RESULTED IN LIMITED CLINICAL APPLICATION.HOWEVER,THE RECENT DEVELOPMENT OF A DEPTH RESOLVED SURFACE COIL SYSTEM (DRESS) HAS ALLOWED THE PERFORMANCE OF 31P-MRS USING WHOLE BODY MAGNETIC RESONANCE IMAGING (MRI) SYSTEMS.THREE PILOT 31P-MRS STUDIES WERE PERFORMED IN PIGS,DOGS AND HUMANS USING A WHOLE BODY MRI SYSTEM.THE NAD+NADH/PI RATIO IN PORCINE LIVERS DECREASED DURING PROLONGED COLD IS CHEMIA.HIGH ENERGY PI WAS PRODUCED IN CANINE LIVERS AFTER REPERFUSION WITH OXYGENATED BLOOD.IN VIVO 31P-MRS WAS PERFORMED CLINICALLY AND MAY IN THE FUTURE PLAY SOME ROLE IN THE ASSESSMENT OF PATIENTS WITH CIRRHOSIS.IN CENTERS THAT HAVE MRIFACILITIES,ORGAN VIABILITY MAY BE ASSESSED AFTER BRAIN DEATH CRITERIA HAVE BEEN SATISFIED AND CONSENT GIVEN FOR ORGAN DONATION.

磁共振波谱（MRS）是一种非侵入性的测量体内化学物质浓度的方法。31 P-MRS已被用于评估小动物离体器官的活性。在有限的临床应用中，尺寸限制已被排除。然而，最近研制的深度分辨表面线圈系统（Dress）已使全身磁共振成像（MRI）能进行~（31）P-MRS在猪中进行了三项初步31 P-MRS研究，应用全身MRI系统对犬和人进行了研究。在长期冷缺血过程中，猪肝脏中NAD+NADH/PI比值降低。氧合血再灌注后，犬肝脏中产生高能PI。在体31 P-MRS是一种辅助诊断，将来可能在肝硬化患者的评估中发挥重要作用。在有MRI设施的中心，在满足脑死亡标准并同意器官捐献后，可评估器官活力。

项目成果

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橋倉泰彦・他: "肝移植術中術後の凝固線溶糸の変動に関する研究" 外科. 58・2. 205-209 (1996)

Yasuhiko Hashikura 等：“肝移植期间和之后凝血和纤维蛋白溶解变化的研究”Surg. 58・2 (1996)。

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橋倉 泰彦・川崎 誠治 他: "成人患者に対する生体部分肝移植、新外科学体系" 中山書店、東京, 8 (1997)

Yasuhiko Hashikura、Seiji Kawasaki 等：“成人患者活体部分肝移植，一种新的手术系统” Nakayama Shoten，东京，8 (1997)

Hashikura Y,Kawasaki S,et al (7).: "Donor selection for livingrelated liver transplantation." Transplant Proc. 29. 3410-3411 (1997)

Hashikura Y,Kawasaki S,et al (7).：“活体相关肝移植的供体选择”。