31P-MAGNETIC RESONANCE SPECTROSCOPY IN EVALUATING HEPATIC FUNCTION : A POSSIBLE APPLICATION IN DONOR ASSESSMENT IN DONOR ASSESSMENT PRIOR TO LIVER TRANSPLANTATION

磁共振波谱(MRS)是一种非侵入性的测量活体内化学物质浓度的方法。31P-MRS已被用来评估小型动物离休器官的活性。然而，由于受到限制，临床应用有限。然而，最近发展的深度分辨表面线圈系统(DRESS)允许使用全身磁共振成像(MRI)系统进行31P-MRS。在猪身上进行了Pilot 31P-MRS研究。狗和人使用全身核磁共振系统。猪肝脏中NAD-NADH/PI比值在长期寒冷中下降。狗肝脏经氧合血再灌注后产生高能量PI。体内31P-MRS已在临床上进行，并在未来可能在评估循环系统患者中发挥一些作用。在有MRIFIITIES的中心，器官存活可能在满足脑死亡标准并同意器官捐赠后进行评估。

MAGNETIC RESONANCE SPECTROSCOPY (MRS) IS A NONINVASIVE METHOD OF MEASURING THE CONCENTRATION OF CHEMICAL SUBSTANCES IN VIVO.31P-MRS HAS BEEN USED TO ASSESS THE VIABILITY OF ISOLATED ORGANS IN SMALL ANIMALS.SIZE CONSTRAINTS HAVE RESULTED IN LIMITED CLINICAL APPLICATION.HOWEVER,THE RECENT DEVELOPMENT OF A DEPTH RESOLVED SURFACE COIL SYSTEM (DRESS) HAS ALLOWED THE PERFORMANCE OF 31P-MRS USING WHOLE BODY MAGNETIC RESONANCE IMAGING (MRI) SYSTEMS.THREE PILOT 31P-MRS STUDIES WERE PERFORMED IN PIGS,DOGS AND HUMANS USING A WHOLE BODY MRI SYSTEM.THE NAD+NADH/PI RATIO IN PORCINE LIVERS DECREASED DURING PROLONGED COLD IS CHEMIA.HIGH ENERGY PI WAS PRODUCED IN CANINE LIVERS AFTER REPERFUSION WITH OXYGENATED BLOOD.IN VIVO 31P-MRS WAS PERFORMED CLINICALLY AND MAY IN THE FUTURE PLAY SOME ROLE IN THE ASSESSMENT OF PATIENTS WITH CIRRHOSIS.IN CENTERS THAT HAVE MRIFACILITIES,ORGAN VIABILITY MAY BE ASSESSED AFTER BRAIN DEATH CRITERIA HAVE BEEN SATISFIED AND CONSENT GIVEN FOR ORGAN DONATION.