Epidemiology and Control of Filariasis in Sri Lanla

1.马塔拉省班氏乌chereria bancroti感染情况(1)共检测3384人。微丝蚴（mf）率为5.1%。丝虫热123例（5.1%），象皮病/水肿78例（3.3%）。(2)丝虫病循环抗原阳性率为20.7%，明显高于常规方法。抗原血症水平与血液中mf密度密切相关。发现许多“抗原（+）和mf（-）”人。在抗原性贫血调查之前，它们构成了我们所不知道的新实体。6 mg/kg /年单剂量乙基卡马嗪（DEC）治疗的效果：6个月时，DEC单剂量使mf计数从原来的100%减少到20%，12个月时减少到27%。如果每年重复，每年的剂量将大大降低丝虫传播的可能性。马塔拉省蚊媒研究(1)致倦库蚊感染率4.9%。受感染的蚊子被收集了一年，这表明丝虫传播全年都在发生。(2)氯菊酯浸渍幕帘可有效降低蚊虫叮咬密度，持续22周。其他活性测定抗丝虫药血清浓度和测定循环抗原水平的简单方法已经开发出来。将PCR成功应用于2种淋巴丝虫病的诊断。

1.The situation of Wuchereria bancrofti infection in Matara(1) A total of 3384 people were examined. The microfilaria (mf) rate was 5.1%. There were 123 cases (5.1% of those examined) with filarial fever and 78 cases (3.3%) with elephantiasis/edema.(2) The positive rate of filarial circulating antigen was 20.7%, which was much higher than those obtained using conventional methods. The level of antigenemia was closely related to mf densities in the blood. Many 'antigen (+) and mf (-)' people were found. They constitute a new entity unknown to us before the antigenemia survey.2.The effect of annual single-dose diethylcarbamazine (DEC) treatment at 6 mg/kgThe single dose of DEC reduced mf count from the original 100% to 20% at 6 months, and to 27% at 12 months. If repeated yearly, the annual doses would reduce filarial transmission potential sharply.3.Studies on mosquito vectors in Matara(1) Mosquito (Culex quinquefasciatus) infection rate was 4.9%. Infected mosquitoes were collected through a year, indicating that tha filarial transmission occurs year-round.(2) Permethrin impregnated curtain was effective to reduce mosquito biting densities for the period of 22 weeks.4.Other activitiesSimple methods to determine serum concentration of anti-filarial drugs, and to measure circulating antigen level have been developed. PCR was successfully applied for the diagnosis of 2 species of lymphatic filariasis.