Comparative Study of ATL and HTLV-I Related Diseases

ATL与HTLV-I相关疾病的比较研究

• 批准号: 08042008
• 负责人: YAMAGUCHI Kazunari
• 金额: $ 2.24万
• 依托单位: Kumamoto University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for international Scientific Research
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08042008/
• 关键词: HTLV-I; Costa Rica; Indonesia; Florida; Egypt; ATL; HAM

HTLV-I is a retrovirus associated with adult T-cell leukemia (ATL), spastic paraplegia (HAM/TSP), HTLV-I uveitis and possibly other diseases.Seroepidimiological studies have been shown distinct geographic endemic clusters of HTLV-I infection and its associated diseases in Southwestern Japan, the Caribbean Basin, South and Central America and Central Africa.Although the actual incidence of HTLV-I carriers in Asia and Central America is difficult to assess, and values of 0% to 37% have been reported.Results : (1) Costa Rica : The subjects were 86 patients with various diseases and 25 blood donors in National Children's Hospital in San Jose and 64 psychiatric patients. Three out of 86 patients in hospital were positive for HTLV-I.All of them are female and black from Caribbean Coast. This area is highly endemic for HTLV-I.(Dr.Jose Bonilla)(2) Indonesia : The subjects were 500 patients with various diseases and 100 blood donors and 100 healthy volunteers at Kristen Indonesia University Hospital. The only one case in this study was indeterminate for HTLV-I.It should be concluded that HTLV-I is not endemic in Jakarta. (Dr.Yunus Tanggo)(3) Miami (Florida) : The subjects were 40 patients with uveitis. All samples were negative for HTLV-I.(Dr.Janet Davis)(4) Egypt : We found two patients with HAM/TSP in the Neurology Department of Cairo University. Both patients were males (24,26 years old). (Dr.Ahmed Gohary)

HTLV-I是一种与成人t细胞白血病（ATL）、痉挛性截瘫（HAM/TSP）、HTLV-I葡萄膜炎和可能的其他疾病相关的逆转录病毒。血清流行病学研究表明，HTLV-I感染及其相关疾病在日本西南部、加勒比盆地、南美洲和中美洲以及中非存在明显的地理地方性聚集性。虽然htlv - 1型携带者在亚洲和中美洲的实际发病率难以评估，但有报道的数值为0%至37%。结果：(1)哥斯达黎加：研究对象为圣何塞国立儿童医院各类疾病患者86例，献血者25例，精神病患者64例。86例住院患者中有3例HTLV-I阳性。他们都是来自加勒比海岸的黑人女性。该地区是HTLV-I的高度流行地区。印度尼西亚：研究对象是印度尼西亚克里斯汀大学医院的500名各种疾病患者、100名献血者和100名健康志愿者。本研究中仅有1例HTLV-I不确定。应该得出结论，HTLV-I在雅加达不是地方性的。（Dr.Yunus Tanggo）迈阿密（佛罗里达）：研究对象是40名葡萄膜炎患者。所有样本HTLV-I均为阴性。(4)埃及：我们在开罗大学神经内科发现了两名患有HAM/TSP的患者。两例患者均为男性（24岁、26岁）。(格哈力Dr.Ahmed)

项目成果

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Takemoto S.: "Primary adult T-cell leukemia of bone : two patients with primary bone tumor showing monoclonal integration of HTLV-I." Leukemia. 10. 333-337 (1996)

Takemoto S.：“原发性成人骨 T 细胞白血病：两名原发性骨肿瘤患者显示 HTLV-I 单克隆整合。”