Treatment of adult T cell leukemia and antoimmune diseases by extracorporeal photochemotherapy

体外光化疗治疗成人T细胞白血病及抗免疫性疾病

• 批准号: 01570691
• 负责人: YAMAGUCHI Kazunari
• 金额: $ 1.34万
• 依托单位: Kumamoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1989
• 资助国家: 日本
• 起止时间: 1989 至 1991
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-01570691/
• 关键词: Photopheresis; ATL; Autoimmune diseases; PUVA therapy; Photochemotherapy; Cutaneous T cell lymphoma; PUVA; PSS; 皮膚リンパ腫; CTCL; 8・MOP; 慢性関節リウマチ

Since the combination of oral therapy of a photoactive drug, 8-methoxypsoralen (8-MOP), and exposure to a high-intensity, Ion, -wave ultraviolet-light system resulted in complete clearing of energized psoriasis in the 1970's, psoralen and long-wave ultraviolet li, ht (PUVA) therapy has become a routine form of dermatologic therapy for skin diseases including cutaneous T-cell lymphoma (CTCL).Edelson et al., developed the technique of extracorporeal photochemotherapy (photopheresis) in which the bully coat is treated with PUVA before it is retumed to the patient. In patients with leukemia cutaneous T-cell lymphoma, this therapy has attempted in improvement of the disease.We have attempted to apply this therapy to certain patients with adult T-cell leukemia (ATL), which is frequently encountered in the southwestern islands of Japan and the Caribbean basin, ; and characterized by the proliferation of transformed CD4 positive cells. This disease sometimes infiltrates the skin similarly to CTCL, and. patients with ATL progress to hi, h white blood cell counts, hypercalcemia, hepatosplenomec, aly, and elevated levels of lactic dehydroenase (LDH) in the serum. The Proo'nosis for 'ATL is extremely poor, and we are desperately in need of new therapies.We have applied photopheresis to patients with progressive systemic sclerosis (PSS), a systemic disease caused by activated mononuclear cells and characterized by excessive collagen deposition in the skin and internal or, ans associated with the expression of autoimmune phenomena. We report here on ATL patients and PSS patients, evaluation, the therapeutic effects.

自从口服光活性药物8-甲氧补骨脂素(8-MOP)和暴露于高强度离子波紫外线系统导致银屑病完全清除以来，在20世纪70年代的S，补骨脂素和长波紫外线疗法已经成为包括皮肤T细胞淋巴瘤(CTCL)在内的皮肤病的常规皮肤科治疗形式。Edelson等人开发了体外光化学疗法(光脱落)，即在给患者之前用PUVA治疗水疱性皮肤病。在白血病皮肤T细胞淋巴瘤患者中，这种疗法试图改善这种疾病。我们试图将这种疗法应用于某些成人T细胞白血病(ATL)患者，这种患者经常发生在日本西南部岛屿和加勒比海盆地，其特征是转化的CD4阳性细胞增殖。这种疾病有时会像CTCL一样渗入皮肤，而且。ATL患者进展为Hi，h白细胞计数，高钙血症，肝脾肿胀，血清乳酸脱氢酶(LDH)水平升高。ATL的预后非常差，我们迫切需要新的治疗方法。我们将光分离术应用于进行性系统性硬化症(PSS)患者，PSS是一种由激活的单个核细胞引起的全身性疾病，其特征是皮肤和内部胶原过度沉积，与自身免疫现象的表达有关。我们报告ATL患者和PSS患者的评估和治疗效果。

项目成果

Yamaguchi K: "HTLV-I infection and diseases" J. Med. Lab. Sci.5. 31-34 (1991)

Yamaguchi K：“HTLV-I 感染和疾病” J. Med。

Futami G,Kiyokawa T,Yamaguchi K,et al.: "Treatment of adult T cell leukaemia by extracorporeal photochemotherapy" Leukemia and Lymphoma. 2. (1990)

Futami G、Kiyokawa T、Yamaguchi K 等人：“体外光化疗治疗成人 T 细胞白血病”白血病和淋巴瘤。

山口 一成他: "フォトフェレーシスによるATL,PSSの治療" 日本輸血学会雑誌. 37. 70-72 (1991)

Kazunari Yamaguchi 等人：“通过光采术治疗 ATL 和 PSS”，日本输血学会杂志 37. 70-72 (1991)。

山口 一成: "ATLとHTLVーI関連疾患" 日本醫事新報. 3530. 7-12 (1991)

Kazunari Yamaguchi：“ATL 和 HTLV-I 相关疾病”日本医学报纸 3530. 7-12 (1991)。

Yamaguchi K, Kiyokawa T, Ishii T, et al.: "Pathogenesis of adult T cell leukemia from clinical pathologic features" Human Retrovirology : HTLV. 163-170 (1990)

Yamaguchi K、Kiyokawa T、Ishii T 等人：“成人 T 细胞白血病的临床病理特征的发病机制”人类逆转录病毒学：HTLV。