Mapping of the human ribosomal protein genes
Mapping of the human ribosomal protein genes
批准号:
08044308
负责人:
KENMOCHI Naoya
金额:
$2.37万
依托单位国家:
日本
项目类别:
Grant-in-Aid for international Scientific Research
财政年份:
1996
资助国家:
日本
项目状态:
已结题
起止时间:
1996 至 1997
中文摘要
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英文摘要
We are intrigued by the possibility that deficiencies of ribosomal protein (rp) genes might cause certain chromosomal disorders in humans. To explore this possibility, we have been systematically mapping the estimated 80 human rp genes. Since localization of rp genes is complicated by the existence of processed pseudogenes, "intron trapping" was devised to identify PCR-detectable sequence-tagged sites (STSs) at introns.We generated 75 STSs specific to intron containing rp genes and then assigned them to individual human chromosomes by typing human-rodent hybrid cell lines. The gene were placed more precisely on the physical map of the human genome by typing radiation hybrids or screening YAC libraries. Fifty-one previously unmapped rp genes were localized, and 24 previously reported rp gene localizations were confirmed, refined or corrected. Though functionally related and coordinately expressed, the 75 mapped genes are widely dispersed : both sex chromosomes and at least 20 of the 22 autosomes carry one or more rp genes. Chromosome 19, known to have a high gene density, contains an unusually large number of rp genes (12). This map provides a foundation for studying the possible roles of ribosomal protein deficiencies in chromosomal and Mendelian disorders.
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Nanda,I.: "The intron-containing ribosomal protein-encoding genes L5,L7a and L37a are unlinked in chicken." Gene. 170. 159-164 (1996)
Nanda,I.:“含有内含子的核糖体蛋白编码基因 L5、L7a 和 L37a 在鸡中是不连锁的。”
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Kenmochi, N.: "A Map of 75 Human Ribosomal Protein Genes" Gemome Research. (in press).
Kenmochi, N.:“75 个人类核糖体蛋白基因图谱”Gemome Research。
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Nanda,I.,Tanaka,T.,Schmid,M.: "The intron-containing ribosomal protein-encoding genes L5,L7a and L37a are unlinked in chicken." Gene. 170. 159-164 (1996)
Nanda,I.,Tanaka,T.,Schmid,M.:“含有内含子的核糖体蛋白编码基因 L5、L7a 和 L37a 在鸡中是不连锁的。”
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Kenmochi,N.: "U14 snoRNAs are encoded in introns of human ribosomal protein S13 gene." Biochem.Biophys.Res.Commun.228. 371-374 (1996)
Kenmochi,N.:“U14 snoRNA 是在人核糖体蛋白 S13 基因的内含子中编码的。”
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Quay, I.K.E., Toku, S., Tanaka, T.: "Sequence requirement for nucleolar localization of rat ribosomal protein L31." Eur.J.Cell Biol.69. 151-155 (1996)
Quay, I.K.E.、Toku, S.、Tanaka, T.:“大鼠核糖体蛋白 L31 核仁定位的序列要求。”
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Loss of RNA modification and autoimmune diseases: a novel mechanism of the SLE pathogenesis
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批准号:24659476
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.33万
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财政年份:2012
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负责人:KENMOCHI Naoya
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依托单位:
RNA modification and self-discrimination : A possible link to the pathogenesis of autoimmune disease
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批准号:22659186
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.11万
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财政年份:2010
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负责人:KENMOCHI Naoya
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依托单位:
Ribosomal abnormalities and human diseases: Molecular pathogenesis of ribosomopathies
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批准号:22370065
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.98万
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财政年份:2010
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负责人:KENMOCHI Naoya
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依托单位:
Intron evolution and small non-coding RNAs
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批准号:15310135
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.98万
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财政年份:2003
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负责人:KENMOCHI Naoya
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依托单位:
Analysis of highly organized functions of the ribosome
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批准号:14035103
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$39.87万
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财政年份:2002
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负责人:KENMOCHI Naoya
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依托单位:
Development of DNA chips for ribosomal protein genes
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批准号:11694300
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项目类别:Grant-in-Aid for Scientific Research (B).
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资助金额:$2.75万
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财政年份:1999
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负责人:KENMOCHI Naoya
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依托单位:
Defects of ribosomal protein genes and human chromosomal disorders.
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批准号:07807020
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.34万
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财政年份:1995
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负责人:KENMOCHI Naoya
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依托单位:
海外基金