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Forensic pathological criteria of sudden infant death syndrome (SIDS) diagnosis

婴儿猝死综合征（SIDS）诊断的法医病理标准

基本信息

批准号：
08307006
负责人：
TAKATSU Akihiro
金额：
$ 8万
依托单位：
The Jikei University School of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
1996
资助国家：
日本
起止时间：
1996 至 1998
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08307006/
关键词：
sudden infant death syndrome sudden infant death SIDS prone position postmortem protocol suffocation ferritin transferrin 乳幼児突然死剖検診断疫学調査ウィルス性肺炎

项目摘要

Three hundred and seven forensic autopsy cases of sudden infant death were collected from 31 departments of forensic medicine in Japan and statistically analysed from the various view points, such as time of death, mode of death, ante mortem clinical symptoms, death scene investigation including sleeping position, autopsy diagnosis and autopsy findings. Of total cases 39.7% were diagnosed the cause of death as sudden infant death syndrome (SIDS) and 61.5% of SIDS cases were found dead in prone position. On the basis of these analytical results, we proposed forensic pathological criteria or minimal requirements for diagnosis of SIDS.According to the criteria, SIDS always should be diagnosed after thorough autopsy of the deceased and simultaneously complete deny of the external death, caused by murder, child abuse, accidental asphyxiation etc. When external death is suspected from death scene investigation and sleeping position, particularly prone position, we should not diagnosed SIDS.As special communications we studied on analysis of judicial precedents about sudden infant death cases, immunohistochemical analysis of transferrin and ferritin in the brain from sudden infant death cases, pulmonary neuro endocrine distribution and fatty change of the lever cells in SIDS cases.

从日本31个法医学部门收集了307例婴儿猝死的法医学尸检资料，从死亡时间、死亡方式、死前临床症状、死亡现场调查（包括睡姿）、尸检诊断和尸检结果等方面进行了统计分析。婴儿猝死综合征（SIDS）占39.7%，其中61.5%的婴儿猝死综合征患儿为俯卧位死亡。在此基础上，提出了法医病理学诊断SIDS的标准或最低要求，即在对死者进行全面尸检，同时完全否认由谋杀、虐待儿童、意外窒息等原因造成的外部死亡的情况下，才能诊断为SIDS;当从死亡现场勘查和睡姿，特别是俯卧位等方面怀疑为外部死亡时，作为专题交流，我们对婴儿猝死案例的司法判例分析，婴儿猝死案例脑内转铁蛋白和铁蛋白的免疫组化分析，婴儿猝死案例肺神经内分泌分布和脂肪细胞的改变进行了研究。