Chronic skeletal muscle pain and regeonal hemodynamic abnormality

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1) Effect of cold pressor test (CPT) on resting masseter muscle hemodynamics.Since CPT was reported to evoke an increase of muscle sympathetic nerve activity in the human skeletal muscle (Victor et al.1987), CPT-induced hemodymanic change in the resting human masseter muscle was measured by using a near infrared spectroscopy device. Results : CPT induced strong increase in intramuscular blood volume and oxygen saturation levels. Moreover, after cessation of 4 degree C CPT task clear rebound Hb decrease was demonstrated. Therefore it can be speculated that increase in muscle sympathetic nerve activity induces hyperemia in normal subjects.2) Effect of alpha and beta adrenergic blocking agents on intramuscular hemodynamic changes.This study evaluated that the effect of intravenous infusion of non-selective alpha- and beta-adrenergic blocking agents on masseter muscle hemodynamics. Results : Intramuscular blood volume and oxygen saturation levels significantly increased by intravenous infusion of alpha blocking agent and trended to decrease by beta blocking agent.3) Comparison of hemodynamic response to CPT between healthy subjects and chronic trapezius muscle pain subjects.This study determined the difference in blood volume of the upper trapezius muscle area between normal and chronic shouder muscle pain subjects during CPT.Results : In both group of subjects the mean blood volume increased above the baseline livel during CPT,however, pain subjects exibited significantly lower mean blood volume during CPT.These results suggest that intramuscular hemodynamic abnormality might be related to the chronic muscle pain pathophysiology.