Immuno-Gene Therapy for the Oral Squamous Cell Carcinoma using with Anti-Tumor Cytotoxic T-Lymphocytes.

针对头颈部鳞状细胞癌，包括口腔鳞状细胞癌，已经进行了大量的MHC限制性抗肿瘤细胞毒性T淋巴细胞的研究。然而，这通常是很难实现的。造成这种困难的原因之一，是肿瘤细胞表面缺乏CD8O分子。我们用腺病毒载体诱导CD8O分子进入肿瘤细胞。CD80修饰的人肿瘤细胞和IL-12可产生高效的抗肿瘤细胞毒性T淋巴细胞。然而，不能产生足够数量的效应细胞用于患者的治疗。

Many trials for the generation of MHC-restricted anti-tumor cytotoxic T lymhocytes against squamous cell carcinoma of head and neck region including oral cavity, have been studied. However, it is usually difficult toachieve.One of the reasons of this difficulty, is the lack of CD8O molecules on the surface of tumor cells. We induced the CD8O molecules into the tumor cells using adeno-vilus vectors. Efficient generation of anti-tumor cytotoxic T lymphocytes are generated with CD8O-modified human tumor cells and IL-12. However, the sufficient number of effector cells for the patients therapy can not be generated.