Immuno-Gene Therapy for the Oral Squamous Cell Carcinoma using with Anti-Tumor Cytotoxic T-Lymphocytes.

使用抗肿瘤细胞毒性 T 淋巴细胞对口腔鳞状细胞癌进行免疫基因治疗。

• 批准号: 08457541
• 负责人: TAKAHASHI Yuzo
• 金额: $ 1.54万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08457541/
• 关键词: Immuno-Gene Therapy; MHC-restricted anti-tumor cytotoxic T-lymhocytes; Oral squamous cell carcinoma; CD80-modified human tumor cells; 特異的免疫療法; 腫瘍重度遺伝子治療; 口腔扁平上皮癌; 腫瘍免疫遺伝子治療; 腫瘍特異的細胞障害性Tリンパ球(CTL); CD80; IL-12

Many trials for the generation of MHC-restricted anti-tumor cytotoxic T lymhocytes against squamous cell carcinoma of head and neck region including oral cavity, have been studied. However, it is usually difficult toachieve.One of the reasons of this difficulty, is the lack of CD8O molecules on the surface of tumor cells. We induced the CD8O molecules into the tumor cells using adeno-vilus vectors. Efficient generation of anti-tumor cytotoxic T lymphocytes are generated with CD8O-modified human tumor cells and IL-12. However, the sufficient number of effector cells for the patients therapy can not be generated.

已经研究了许多针对头颈区域（包括口腔）鳞状细胞癌产生 MHC 限制性抗肿瘤细胞毒性 T 淋巴细胞的试验。然而，这通常很难实现。造成这一困难的原因之一是肿瘤细胞表面缺乏CD8O分子。我们使用腺病毒载体将 CD8O 分子诱导进入肿瘤细胞。使用 CD8O 修饰的人肿瘤细胞和 IL-12 可以有效生成抗肿瘤细胞毒性 T 淋巴细胞。然而，无法产生足够数量的效应细胞用于患者治疗。