Immuno-Gene Therapy for the Oral Squamous Cell Carcinoma using with Anti-Tumor Cytotoxic T-Lymphocytes.

针对包括口腔在内的头颈部鳞状细胞癌的MHC限制性抗肿瘤细胞毒性T细胞的产生已经进行了许多试验。然而，这一过程通常很难实现，其原因之一是肿瘤细胞表面缺乏CD 80分子。我们用腺病毒载体将CD_（80）分子导入肿瘤细胞。抗肿瘤细胞毒性T淋巴细胞的有效产生用CD 8 O修饰的人肿瘤细胞和IL-12产生。然而，不能产生足够数量的效应细胞用于患者治疗。

Many trials for the generation of MHC-restricted anti-tumor cytotoxic T lymhocytes against squamous cell carcinoma of head and neck region including oral cavity, have been studied. However, it is usually difficult toachieve.One of the reasons of this difficulty, is the lack of CD8O molecules on the surface of tumor cells. We induced the CD8O molecules into the tumor cells using adeno-vilus vectors. Efficient generation of anti-tumor cytotoxic T lymphocytes are generated with CD8O-modified human tumor cells and IL-12. However, the sufficient number of effector cells for the patients therapy can not be generated.