Optimising haemodynamics in complex stented arteries

优化复杂支架动脉的血流动力学

• 批准号: LP150100233
• 负责人: Prof Peter Barlis
• 金额: $ 32.77万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-02-04 至 2021-12-05
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP150100233
• 关键词: Optimising; haemodynamics; complex; stented; arteries

This project aims to optimise the hemodynamics (blood flow) in coronary arteries with high curvatures and bifurcations. Experience has shown that the build-up of plaque — and the resulting occlusion of blood flow — tends to occur in these complex arterial regions. The most common therapeutic strategy is the insertion of a stent to prop open the artery. However, the nature of the geometry often leads to post-stenting complications such as restenosis and thrombosis, ultimately resulting in negative outcomes. In this project, advanced research methods from fluid dynamics and optimisation and control will be used to potentially minimise these highly undesirable effects.

该项目旨在优化具有高曲率和分叉的冠状动脉的血液动力学（血流）。经验表明，斑块的积聚-以及由此导致的血流阻塞-往往发生在这些复杂的动脉区域。最常见的治疗策略是插入支架以撑开动脉。然而，几何形状的性质通常导致支架植入后并发症，例如再狭窄和血栓形成，最终导致负面结果。在这个项目中，来自流体动力学和优化和控制的先进研究方法将被用来最大限度地减少这些非常不受欢迎的影响。