Aortic arch haemodynamics in adult women with Turner syndrome: A numerical investigation into obesity-related factors

特纳综合征成年女性的主动脉弓血流动力学：肥胖相关因素的数值研究

• 批准号: NE/T014113/1
• 负责人: Asimina Kazakidi
• 金额: $ 1.62万
• 依托单位: University of Strathclyde
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=NE%2FT014113%2F1
• 关键词: Aortic; arch; haemodynamics; adult; women

EPSRC : Lauren Johnston : EP/R513349/1Girls with Turner syndrome (TS), a chromosomal condition in which a female has complete or partial absence of the second sex chromosome, present a unique group of patients, with an increased risk of cardiovascular disease. Mortality rates are three times higher in TS women compared with the general population, and life expectancy is reduced by up to 13 years - the most common cause of death being from cardiovascular disease. Children with TS also have a greater underlying predisposition to obesity, which is found to increase with age. Since the mid 1900s extensive research has led to advancements in the treatment of Turner syndrome: growth hormone therapy can increase final adult height, and reproductive treatment can assist with infertility. However, cardiovascular diseases affecting girls and women with TS remain under-researched, and remains the leading cause of death. Our research aims to contribute to one of the key cardiovascular research priorities outlined in a scientific statement from the American Heart Association, which is to elucidate the pathogenesis of increased cardiovascular morbidity and mortality in women with TS compared with the general population and determine the contributions of atherosclerotic disease, hypertension, and obesity. The proposed project will increase our understanding of the haemodynamic environment and, ultimately, flow-related cardiovascular disease markers in patients with Turner syndrome by reconstructing 3D models of the aorta and performing blood flow simulations, using computational fluid dynamic methods. Current research in the UK has highlighted some aspects of the aortic haemodynamics in children with Turner syndrome. The project proposed for the Mitacs Globalink placement complements the scope of this research by addressing questions relating to the adult Turner syndrome population. Without the proposed new collaboration between the UK and Canadian research groups, the student would not be able to extend the study cohort to adult TS patients. The research carried out at the University of Strathclyde combined with the prospective research to be carried out at the University of Toronto will provide the first ever analysis of blood flow in both paediatric and adult Turner syndrome patients. The project is highly multi-disciplinary within the broad fields of Biomedical Engineering, Fluid Mechanics, and Paediatric Medicine, and in close collaboration with clinicians at both Scottish and Canadian hospitals. This research could have an immeasurable impact for Turner syndrome patients in both the UK and Canada, improving significantly their personalised care and quality of life.

EPSRC：Lauren Johnston：EP/R513349/1Girls患有Turner综合征（TS），这是一种染色体疾病，其中女性完全或部分缺乏第二性性别染色体，呈现出独特的患者，具有心血管疾病风险增加的独特患者。与普通人群相比，TS妇女的死亡率高三倍，预期寿命降低了13年 - 最常见的死亡原因是心血管疾病。 TS儿童的肥胖症还具有更大的潜在倾向，发现随着年龄的增长而增加。自1900年代中期以来，广泛的研究导致了特纳综合症治疗的进步：生长激素疗法可以提高最终的成人身高，而生殖治疗可以帮助不孕。但是，影响患有TS的女孩和妇女的心血管疾病仍未得到研究，并且仍然是死亡的主要原因。我们的研究旨在为美国心脏协会的一项科学陈述中概述的主要心血管研究重点之一做出贡献，这是为了阐明与普通人群相比，TS女性心血管发病率和死亡率增加的发病机理，并确定动脉粥样硬化疾病，高血压，高血压和肥胖症的贡献。拟议的项目将通过使用计算流体动力学方法来重建主动脉的3D模型并进行血液流量模拟，从而提高我们对特纳综合征患者的血液动力学环境的理解，并最终在特纳综合征患者中与流动相关的心血管疾病标记。英国目前的研究强调了特纳综合征儿童主动脉血流动力学的某些方面。该项目为MITACS Globalink放置提供了补充，通过解决与成人特纳综合症人群有关的问题，可以补充这项研究的范围。没有英国与加拿大研究小组之间的新合作，该学生将无法将研究队列扩展到成人TS患者。在Strathclyde大学进行的研究与多伦多大学进行的前瞻性研究相结合，将提供有关儿科和成人特纳综合症患者血液流量的首次分析。该项目在生物医学工程，流体力学和小儿医学的广泛领域中是高度多学科的，并且与苏格兰和加拿大医院的临床医生密切合作。这项研究可能会对英国和加拿大的特纳综合症患者产生不可估量的影响，从而显着改善了他们的个性化护理和生活质量。