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The study for the acceleration on bone formation with growing and the prevention of bone loss with aging

随着生长加速骨形成和预防随着衰老骨质流失的研究

基本信息

批准号：
08458010
负责人：
EZAWA Ikuko
金额：
$ 4.93万
依托单位：
Japan Women's University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
1996
资助国家：
日本
起止时间：
1996 至 1997
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08458010/
关键词：
Osteoporosis,Bone Mineral Density Bone Strength Bone Histomorphometry Osteoporotic Model Rat Egg-Shell Ca Voluntary Exercise Energy Intake 病理研究支援画像解析システムIPAP 成長期ラット運動

项目摘要

The purpose of this study is the examination for the effect of the voluntary exercise and some calcium (Ca) sources on the prevention of osteoporosis. In this study, bone histomorphometry was determined using the IPAP system, which is the Image Processor for Analytical Pathology, and bone mineral density (BMD) and Bone strength were also measured.In 1996, we studied the effect of the exercise an energy intake on bone metabolism using the young rats. At the dissection, the bone samples were taken and the bone specimens for the histomorphometry were made. Then, bone volume, tissue volume, osteoid volume, bone surface, single ravel surface, double ravel surface, and double ravel surface area of each specimen were measured. Thereafter, bone formation rates and mineral apposition rates were analyzed. These datum of the bone histomorphometry indicated that the voluntary exercise could be effective on bone. In 1997, we continued the analisis of the bone histomorphometry. The bone formation rates and mineral apposition rates were analyzed the using several methods. In addition to this, the BMD and the bone strength were measured. All data suggested that the exercise is effective for bone formation. However, inadequate of energy intake affected negativry on bone metabolism.In 1997, we also examined the effect of the Egg-shell Ca and the Toche bark extraction on bone metabolism using the animal model of osteoporosis. The results of these studies suggested that the egg-shell Ca and the Toche bark extraction were effective for the prevention of osteoporosis.

本研究的目的是探讨自愿运动和某些钙源对预防骨质疏松症的作用。本研究采用病理分析图像处理系统（IPAP）进行骨组织形态计量学测定，并测定骨密度（BMD）和骨强度。在解剖时，采集骨样本并制备用于组织形态计量学的骨标本。然后，测量每个标本的骨体积、组织体积、类骨质体积、骨表面、单松解表面、双松解表面和双松解表面面积。此后，分析骨形成率和矿物质沉积率。这些骨组织形态计量学数据表明，随意运动对骨组织有一定的作用。1997年，我们继续进行了骨组织形态计量学分析。采用多种方法分析骨形成率和矿物质沉积率。除此之外，还测量了BMD和骨强度。所有数据表明，运动是有效的骨形成。1997年，我们又利用骨质疏松动物模型，研究了蛋壳钙和托什树皮提取物对骨代谢的影响。这些研究结果表明，蛋壳钙和托什树皮提取物是有效的预防骨质疏松症。