7T PROTON RESONANT FREQUENCY SHIFT & R2* IN FROZEN EXVIVO RENAL TISSUE

7T 质子共振频移

• 批准号: 7722917
• 负责人: Kim Butts-Pauly
• 金额: $ 0.56万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7722917
• 关键词: Computer Retrieval of Information on Scientific Projects Database; Cryosurgery; Freezing; Frequencies; Funding; Grant; Image; Institution; Invasive; Kidney; Magnetic Resonance Imaging; Malignant neoplasm of kidney; Measures; Methods; Protons; Purpose; Renal Tissue; Renal carcinoma; Research; Research Personnel; Resources; Sampling; Source; System; Temperature; Tissues; United States National Institutes of Health; phase change

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. ntroduction Image-guided cryoablation is a minimally invasive therapy for renal cancer. To this end, MR parameters of frozen tissue have been measured with ultrashort TE MR imaging on a low field interventional system [1,2], but understanding of the contribution of the proton resonant frequency shift to the observed phase changes have been limited by the SNR of the frozen tissue at low field. Aims The purpose of this study was to measure the MR parameters of frozen tissue (PRF shift and R2*) on a high field spectrometer. Methods Freshly excised kidney samples were imaged with the Varian INOVA 300 MHz NMR system. Tissue temperature was decreased to 30¿C in steps. To calculate 1H frequency shift with temperature, the baseline frequency was subtracted from the 1H frequency at every temperature. The R2* was calculated from the linewidth.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 介绍 图像引导冷冻消融术是治疗肾癌的一种微创治疗方法。为此，已在低场介入系统上使用超短TE MR成像测量了冷冻组织的MR参数[1，2]，但对质子共振频率偏移对观察到的相位变化的贡献的理解受到低场冷冻组织SNR的限制。 旨在 本研究的目的是在高场谱仪上测量冷冻组织的MR参数（PRF位移和R2*）。 方法 用Varian INOVA 300 MHz NMR系统对新鲜切除的肾脏样品进行成像。组织温度降低至 30 ° C的台阶。为了计算随温度的1H频移，在每个温度下从1H频率中减去基线频率。从线宽计算R2*。