Development of portable near-infrared muscle oximeter using multi-sensor method.

采用多传感器方法开发便携式近红外肌肉血氧计。

• 批准号: 08558090
• 负责人: YAMAMOTO Katsuyuki
• 金额: $ 5.38万
• 依托单位: HOKKAIDO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08558090/
• 关键词: near-infrared light; tissue oximeter; muscle tissue; fat layer; Monte Carlo simulation; optical properties of tissue

A portable tissue oximeter based on two-wavelength near-infrared spectroscopy with multiple photo sensors was developed for a real-time, ambulatory measurement of muscle oxygenation. This oximeter can eliminate the influences of inhomogeneous structure of tissues on the measurement and is useful for quantitative evaluation of muscle oxygenation in the fields of sports and rehabilitation medicine as well as in muscle tissue physiology. Important results of this study are summarized as follows.Development of the portable tissue oximeter : The oximeter was made compact for the ambulatory measurement using LED as a light source. Photo sensors were placed at distances of 20, 30 and 40 mm from the light source for the oxygenation measurement of the muscle with various thicknesses of fat layers. An algorithm for obtaining oxygenation was determined by systematic analyses of reflectance, based on the light diffusion theory and tissue phantom experiments.Correction of the influences of a subcut … More aneous fat layer and the skin : Influence of a subcutaneous fat layer was systematically examined through Monte Carlo simulation, phantom experiments and in vivo measurements. A correction method for decrease in measurement sensitivity due to the presence of a fat layer was established. Effects of the skin and skin blood flow were also studied, and it was found that these effects can be eliminated using an additional near-by photo sensor 3 mm distant from the light source.Evaluation of the system in practical applications : To evaluate the usefulness of the developed system, oxygen transport capacity in the muscle tissue was measured in eleven Olympic athletes of the Nordic combined. Measured transport capacities were clearly higher than those of untrained subjects.In vivo measurement of tissue optical properties : As basic data for determining a mean optical pathlength and for obtaining an absolute oxgenation value, optical properties of muscle tissues were successfully determined at the forearm, without the influence of a fat layer, using time-resolved spectroscopy. Less

研制了一种基于双波长近红外光谱和多个光电传感器的便携式组织血氧仪，用于实时、动态测量肌肉氧合。该血氧计可消除组织结构不均匀对测量的影响，可用于运动医学、康复医学和肌肉组织生理学等领域的肌肉氧合定量评价。本研究的主要结果归纳如下：便携式组织血氧仪的研制：采用LED作为光源，使血氧仪结构紧凑，适合于动态测量。将光传感器放置在距光源20、30和40 mm的距离处，用于测量具有不同厚度脂肪层的肌肉的氧合。根据光散射理论和组织模型实验，通过对反射率的系统分析，确定了一种获得氧合的算法。 ...更多信息 皮下脂肪层和皮肤：通过Monte Carlo模拟、体模实验和体内测量系统地检查皮下脂肪层的影响。建立了由于脂肪层的存在而导致测量灵敏度降低的校正方法。皮肤和皮肤血流的影响也进行了研究，并发现，这些影响可以消除使用一个额外的附近的光传感器3毫米距离的光源。评价该系统在实际应用中：为了评估所开发的系统的有用性，在肌肉组织中的氧运输能力进行了测量，在11个奥运会运动员的北欧组合。测量的传输能力明显高于那些未经训练的subjects.In体内测量组织的光学特性：作为基本数据，用于确定平均光程长度和获得绝对氧合值，肌肉组织的光学特性成功地确定在前臂，没有脂肪层的影响，使用时间分辨光谱。少

项目成果

庭山雅嗣: "近赤外光を用いた筋組織酸素計測の特性解析-マルチセンサ方式による定量計測の可能性-" 第1回生体・生理工学シンポジウム論文集. 189-192 (1996)

Masatsugu Niwayama：“使用近红外光测量肌肉组织氧的特性分析 - 使用多传感器方法进行定量测量的可能性 -”第一届生物和生理工程研讨会论文集 189-192（1996）。

K.Yamamoto: "A near-infrared muscle oximeter that can correct the influence of a subcutaneous fat layer" Proceedings of SPIE. vol.3257. 146-155 (1998)

K.Yamamoto：“一种可以校正皮下脂肪层影响的近红外肌肉血氧计”SPIE 论文集。

M.Niwayama: "Quantitative evaluation of oxygen transport ca-pacity by muscle oxygenation" Proceedings of the 13th Sympo-sium on Biophysical Engineer-ing. 97-100 (1998)

M.Niwayama：“肌肉氧合对氧输送能力的定量评估”第13届生物物理工程研讨会论文集。

庭山雅嗣: "近赤外光を用いた筋組織酸素計測における脂肪層の影響" 電子情報通信学会 技術研究報告. MBE96-42. 51-56 (1996)

Masatsugu Niwayama：“使用近红外光测量脂肪层对肌肉组织氧的影响”IEICE 技术研究报告 51-56 (1996)。

K.Shimizu: "Noninvasive functional imaging of animal brain using near-infrared light" JSME International Conference on New Frontiers in Biomechanical Engineering. 195-198 (1997)

K.Shimizu：“使用近红外光对动物大脑进行无创功能成像”JSME 国际生物力学工程新前沿会议。