Preparation of Arificial Stoma Using Temperature-Responsive Hydrogel

直肠或结肠被某些疾病(如癌症)切除后，腹壁上会形成可供排泄的造口。它是用肠管形成的，然而，它的孔的形状影响了他们的社交生活，因为它主导着造口护理。在此背景下，我们开展了利用温度响应性水凝胶制作完全人工造口的研究。在本项目中，我们的目标是加速水凝胶对温度变化的快速体积相变，以实现井眼的快速启闭系统。此外，还研究了温度敏感型水凝胶与硅橡胶的杂交及其在人工造口开闭式系统中的应用。通常情况下，聚N-异丙基丙烯酰胺(PIPAAm)水凝胶在其周围的表面形成不透水的皮肤层，防止凝胶的消胀和快速收缩。为了控制皮肤层的形成，我们新制备了水凝胶c…。PIPAAm网络接枝聚乙二醇组分的研究较少。我们的概念是，亲水性的聚乙二醇链会在皮肤层形成水路，因此，水可能会在收缩过程中从凝胶中流出。PEG接枝PIPAAm凝胶的收缩速度与接枝率有关，表明在PIPAAm水凝胶中进行聚乙二醇接枝是加速收缩的有效方法之一。对于更亲水的DMAAm，其LCST高于PIPAAm均聚物。用合成的大分子单体制备了新型的接枝了IPAAm和DMAAm共聚物的PIPAAm水凝胶。当我们将PIPAAm的LcST升高到低于大单体的LcST时，高水合大分子单体不会使PIPAAm收缩。一旦温度高于大分子单体的LcST，水凝胶就会迅速收缩。我们还发现，控制接枝链的LCST可以加速PIPAAm水凝胶的收缩。较少

After excision of rectum or colon by some disease such as cancer, stoma that is hole for excretion is built up at an abdominal wall. It was formed using intestinal tube, however, its shape of the hole influence their social life because it dominates stoma care. From this background, we performed the research with respect to fabrication of completely artificial stoma using temperature-responsive hydrogel. In this project, we aimed acceleration of rapid volume phase transition of hydrogel in response to temperature change for rapid open and shut system of the hole. Moreover, hybridization of the temperature-responsive hydrogel and silicone rubber and application of this material to open shut system of artificial stoma were studied.Generally, poly(N-isopropylacrylamide) (PIPAAm) hydrogels form water-impermeable skin layer at the surface around its LCST.This skin layer prevent the gel from deswelling and rapid shrinking. To control the skin layer formation, we newly prepared the hydrogel c … More omposed of PIPAAm network grafted with polyethylene glycol (PEG). Our concept is that the hydrophilic PEG chains would form water path in the skin layer and as a result, water could go out from the gel in course of shrinking. PEG-graft PIPAAm gel showed very rapid shrinking and its rate depended on the grafted ratio of PEG.It was revealed that the PEG-grafting in PIPAAm hydrogel was one of the useful method for acceleration of shrinking.Separately, we prepared macromonomer composed of copolymer of IPAArn and N,N-dimethylacrylamide (DMAAm). For more hydrophilic character of DMAAm, LCST is higher than that of PIPAAm homopolymer. We prepared the novel PIPAAm hydrogel grafted with copolymer of IPAAm and DMAAm using macromonomer prepared. When we increased temperature above LCST of PIPAAm below that of macromonomer, PIPAAm could not shrink by highly hydrated macromonomer. Once we increased temperature above LCST of macromonomer, the hydrogel shrunk very rapidly. We also revealed that controlling of LCST of graft chain could accelerate the shrinking of the PIPAAm hydrogel. Less