Preparation of Arificial Stoma Using Temperature-Responsive Hydrogel

由于某些疾病（如癌症）切除直肠或结肠后，在腹壁上形成一个用于排泄的孔。它是用肠管形成的，然而，它的孔的形状影响着它们的社会生活，因为它主导着造口护理。在此背景下，我们进行了关于使用温度响应水凝胶制造完全人工造口的研究。在本项目中，我们的目标是加速水凝胶随温度变化的快速体积相变，以实现井眼快速开闭系统。此外，还研究了温度响应水凝胶与硅橡胶的杂交及其在人工造口开闭系统中的应用。通常，聚n -异丙基丙烯酰胺（PIPAAm）水凝胶在其LCST周围的表面形成不透水的皮肤层。这层皮肤层防止凝胶膨胀和快速收缩。为了控制皮层的形成，我们用聚乙二醇（PEG）接枝PIPAAm网络制备了一种新型水凝胶。我们的概念是亲水的PEG链会在皮肤层形成水通道，从而在凝胶收缩的过程中使水从凝胶中流出。聚乙二醇接枝PIPAAm凝胶的收缩速度与接枝比例有关。结果表明，在PIPAAm水凝胶中接枝聚乙二醇是一种有效的加速收缩的方法。另外，我们制备了由IPAArn和N，N-二甲基丙烯酰胺（DMAAm）共聚物组成的高分子单体。由于DMAAm具有更强的亲水性，LCST高于PIPAAm均聚物。利用所制备的大单体，制备了IPAAm与DMAAm共聚物接枝的新型PIPAAm水凝胶。将PIPAAm的温度提高到低于单体温度的最低温度以上时，PIPAAm不会被高水合单体收缩。当温度高于单体的lst时，水凝胶迅速收缩。我们还发现，控制接枝链的LCST可以加速PIPAAm水凝胶的收缩。少

After excision of rectum or colon by some disease such as cancer, stoma that is hole for excretion is built up at an abdominal wall. It was formed using intestinal tube, however, its shape of the hole influence their social life because it dominates stoma care. From this background, we performed the research with respect to fabrication of completely artificial stoma using temperature-responsive hydrogel. In this project, we aimed acceleration of rapid volume phase transition of hydrogel in response to temperature change for rapid open and shut system of the hole. Moreover, hybridization of the temperature-responsive hydrogel and silicone rubber and application of this material to open shut system of artificial stoma were studied.Generally, poly(N-isopropylacrylamide) (PIPAAm) hydrogels form water-impermeable skin layer at the surface around its LCST.This skin layer prevent the gel from deswelling and rapid shrinking. To control the skin layer formation, we newly prepared the hydrogel c … More omposed of PIPAAm network grafted with polyethylene glycol (PEG). Our concept is that the hydrophilic PEG chains would form water path in the skin layer and as a result, water could go out from the gel in course of shrinking. PEG-graft PIPAAm gel showed very rapid shrinking and its rate depended on the grafted ratio of PEG.It was revealed that the PEG-grafting in PIPAAm hydrogel was one of the useful method for acceleration of shrinking.Separately, we prepared macromonomer composed of copolymer of IPAArn and N,N-dimethylacrylamide (DMAAm). For more hydrophilic character of DMAAm, LCST is higher than that of PIPAAm homopolymer. We prepared the novel PIPAAm hydrogel grafted with copolymer of IPAAm and DMAAm using macromonomer prepared. When we increased temperature above LCST of PIPAAm below that of macromonomer, PIPAAm could not shrink by highly hydrated macromonomer. Once we increased temperature above LCST of macromonomer, the hydrogel shrunk very rapidly. We also revealed that controlling of LCST of graft chain could accelerate the shrinking of the PIPAAm hydrogel. Less