Preparation of Arificial Stoma Using Temperature-Responsive Hydrogel

由于癌症等疾病切除直肠或结肠后，在腹壁上形成排泄孔即造口。它是利用肠管形成的，然而，它的孔的形状影响他们的社会生活，因为它主导造口护理。在此背景下，我们进行了关于使用温度响应性水凝胶制造完全人工造口的研究。在本项目中，我们的目标是加速响应于温度变化的水凝胶的快速体积相变的快速打开和关闭系统的孔。聚（N-异丙基丙烯酰胺）（PIPAAm）水凝胶通常在其LCST附近的表面形成不透水的表皮层，该表皮层阻止凝胶的去溶胀和快速收缩。为了控制皮肤层的形成，我们新制备了水凝胶c ...更多信息 由接枝有聚乙二醇（PEG）的PIPAAm网络组成。我们的概念是，亲水性PEG链会在表皮层中形成水通道，因此，水可以在收缩过程中从凝胶中出去。PEG接枝PIPAAm水凝胶的收缩速率与PEG的接枝率有关，表明PEG接枝PIPAAm水凝胶是加速PIPAAm水凝胶收缩的有效方法之一。由于DMAAm的亲水性，LCST比PIPAAm均聚物高。利用合成的大分子单体制备了IPAAm和DMAAm共聚物接枝的新型PIPAAm水凝胶。当我们将温度提高到高于PIPAAm的LCST而低于大分子单体的LCST时，PIPAAm不能被高度水合的大分子单体收缩。一旦我们将温度升高到大分子单体的LCST以上，水凝胶就非常迅速地收缩。我们还发现，控制接枝链的LCST可以加速PIPAAm水凝胶的收缩。少

After excision of rectum or colon by some disease such as cancer, stoma that is hole for excretion is built up at an abdominal wall. It was formed using intestinal tube, however, its shape of the hole influence their social life because it dominates stoma care. From this background, we performed the research with respect to fabrication of completely artificial stoma using temperature-responsive hydrogel. In this project, we aimed acceleration of rapid volume phase transition of hydrogel in response to temperature change for rapid open and shut system of the hole. Moreover, hybridization of the temperature-responsive hydrogel and silicone rubber and application of this material to open shut system of artificial stoma were studied.Generally, poly(N-isopropylacrylamide) (PIPAAm) hydrogels form water-impermeable skin layer at the surface around its LCST.This skin layer prevent the gel from deswelling and rapid shrinking. To control the skin layer formation, we newly prepared the hydrogel c … More omposed of PIPAAm network grafted with polyethylene glycol (PEG). Our concept is that the hydrophilic PEG chains would form water path in the skin layer and as a result, water could go out from the gel in course of shrinking. PEG-graft PIPAAm gel showed very rapid shrinking and its rate depended on the grafted ratio of PEG.It was revealed that the PEG-grafting in PIPAAm hydrogel was one of the useful method for acceleration of shrinking.Separately, we prepared macromonomer composed of copolymer of IPAArn and N,N-dimethylacrylamide (DMAAm). For more hydrophilic character of DMAAm, LCST is higher than that of PIPAAm homopolymer. We prepared the novel PIPAAm hydrogel grafted with copolymer of IPAAm and DMAAm using macromonomer prepared. When we increased temperature above LCST of PIPAAm below that of macromonomer, PIPAAm could not shrink by highly hydrated macromonomer. Once we increased temperature above LCST of macromonomer, the hydrogel shrunk very rapidly. We also revealed that controlling of LCST of graft chain could accelerate the shrinking of the PIPAAm hydrogel. Less