Preparation of Arificial Stoma Using Temperature-Responsive Hydrogel

使用温度响应水凝胶制备人工造口

基本信息

批准号：
08558102
负责人：
AOYAGI Takao
金额：
$ 3.65万
依托单位：
Tokyo Women's Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
1996
资助国家：
日本
起止时间：
1996 至 1998
项目状态：
已结题

项目摘要

After excision of rectum or colon by some disease such as cancer, stoma that is hole for excretion is built up at an abdominal wall. It was formed using intestinal tube, however, its shape of the hole influence their social life because it dominates stoma care. From this background, we performed the research with respect to fabrication of completely artificial stoma using temperature-responsive hydrogel. In this project, we aimed acceleration of rapid volume phase transition of hydrogel in response to temperature change for rapid open and shut system of the hole. Moreover, hybridization of the temperature-responsive hydrogel and silicone rubber and application of this material to open shut system of artificial stoma were studied.Generally, poly(N-isopropylacrylamide) (PIPAAm) hydrogels form water-impermeable skin layer at the surface around its LCST.This skin layer prevent the gel from deswelling and rapid shrinking. To control the skin layer formation, we newly prepared the hydrogel c … More omposed of PIPAAm network grafted with polyethylene glycol (PEG). Our concept is that the hydrophilic PEG chains would form water path in the skin layer and as a result, water could go out from the gel in course of shrinking. PEG-graft PIPAAm gel showed very rapid shrinking and its rate depended on the grafted ratio of PEG.It was revealed that the PEG-grafting in PIPAAm hydrogel was one of the useful method for acceleration of shrinking.Separately, we prepared macromonomer composed of copolymer of IPAArn and N,N-dimethylacrylamide (DMAAm). For more hydrophilic character of DMAAm, LCST is higher than that of PIPAAm homopolymer. We prepared the novel PIPAAm hydrogel grafted with copolymer of IPAAm and DMAAm using macromonomer prepared. When we increased temperature above LCST of PIPAAm below that of macromonomer, PIPAAm could not shrink by highly hydrated macromonomer. Once we increased temperature above LCST of macromonomer, the hydrogel shrunk very rapidly. We also revealed that controlling of LCST of graft chain could accelerate the shrinking of the PIPAAm hydrogel. Less

在某些疾病（例如癌症）惊讶的是直肠或结肠后，在腹壁上建立了极端极端的孔。它是使用肠管形成的，但是它的孔形状会影响其社会生活，因为它主导了地面护理。从这种背景来看，我们使用温度响应水凝胶对制造完全人造的地面进行了研究。在这个项目中，我们旨在加速水凝胶的快速体积相变，以响应温度变化，以快速开放和关闭孔的系统。此外，温度响应性水凝胶和硅橡胶的杂交以及该材料在人造地面上的开放式封闭系统中的应用是研究的。基因，聚（N-异丙基酰基酰胺）（Pipaam）水凝胶形成可在其LCST周围的表面上可渗透的皮肤层的水层，并散发出可渗透的皮肤。为了控制皮肤层的形成，我们新准备的水凝胶C…更多地由用聚乙烯乙二醇（PEG）接枝的PIPAAM网络组成。我们的概念是，亲水性钉链会在皮肤层中形成水路，因此，在收缩过程中，水可能会从凝胶中流出。 PEG-GRAFT PIPAAM凝胶显示出非常快速的收缩，其速率取决于钉子的移植比。这表明Pipaam水凝胶中的钉钉是加速缩小的有用方法之一。我们准备了由IPAARN和N-二氨基乙酰乙酰乙酰酰胺层（DMA）（DMA）组成的分子仪组成的宏观分子。对于DMAAM的更多亲水性，LCST高于Pipaam均聚物。我们准备了使用宏观工程师制备的新型PIPAAM水凝胶，该水凝胶用IPAAM和DMAAM的共聚物接枝。当我们将温度升高到巨摩有经剂以下的LCST以上时，Pipaam无法通过高度水合的宏观工程师收缩。一旦我们将温度升高以上是宏观工程师的LCST，水凝胶会非常迅速地收缩。我们还透露，控制移植链的LCST可以加速pipaam水凝胶的收缩。较少的