Static exercise-induced increase in blood pressure in individuals with cervical spinal cord injuries

本文研究了C6 ~ C8颈髓损伤受试者静态运动加压反应的传入和反射通路。在这些受试者中，下行的脊髓上交感神经元和从收缩肌肉经延髓心血管中枢到外周血管的传入通路受损。我们测量了7名SCI受试者和7名年龄匹配的健康对照者在肱二头肌持续收缩2分钟期间的平均动脉血压（MBP）、心率（HR）和血浆去甲肾上腺素（NE）、肾上腺素（E）、肾素活性、血管加压素、醛固酮和人心房钠尿肽浓度。静态运动导致两个SCI的MBP显著增加（P<0.05）（运动前; 74.7（± SD）; [）2.2，静态运动; 81.9（）SY. ±. [] 4.1 mmHg）和对照组（运动前; 101.0（]SY. ±. [）4.2，静态运动; 117.0（]SY. ±. [）4.9 mmHg）。SCI患者运动时HR无变化，而对照组运动时HR增加（P<0.05）（运动前：68.7（± 0.05））。[）3.8，静态运动; 76.0（）SY. ±. [3.1次/分]。在整个实验过程中，SCI中的激素没有显著变化。基于SCI运动期间MBP的显着升高，我们的结果表明SCI受试者中存在功能性心血管控制系统，该系统调节对静态运动的加压反应，独立于心血管延髓控制中心。

We evaluated the afferent and reflex pathways involved in the pressor response to static exercise in subjects with cervical spinal cord injuries (SCI) at C6 to C8 level. In these subjects.the descending supraspinal sympathetic neurons and afferent pathways from the contracting muscles to peripheral vessels via the medullary cardiovascular center are damaged. We measured the mean arterial blood pressure (MBP) , heart rate (HR) and plasma concentrations of norepinephrine (NE) , epinephrine (E) , renin activity, vasopressin, aldosterone and human atrial natriuretic peptide during a 2-min period of sustained contraction of biceps brachii muscle in 7 SCI subjects and 7 age-matched ablebodied control subjects. Static exercise resulted in a significant increase in MBP (P<0.05) in both SCI (pre-exercise ; 74.7 (]SY.+-。[) 2.2, static exercise ; 81.9 (]SY.+-。[) 4.1 mmHg) and control (pre-exercise ; 101.0 (]SY.+-。[) 4.2, static exercise ; 117.0 (]SY.+-。[) 4.9 mmHg). There was no change in HR during exercise in SCI,while HR increased (P<0.05) during exercise in control subjects (pre-exercise ; 68.7 (]SY.+-。[) 3.8, static exercise ; 76.0 (]SY.+-。[) 3.1 beats/min). There were no significant changes in the hormones in SCI throughout the experiment. Based on the significant rise in MBP during exercise in SCI,our results indicate the presence of a functional cardiovascular control system in SCI subjects, which regulates the pressor response to static exercise is independent of the cardiovascular medullary control center.