权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Muscle sympathetic nerve activity during isometric exercise in patients with cerebrovascular accidents.

脑血管意外患者等长运动期间的肌肉交感神经活动。

基本信息

批准号：
14571369
负责人：
TAJIMA Fumihiro
金额：
$ 1.86万
依托单位：
HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2003
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14571369/
关键词：
Sympathetic nervous system Cerebrovascular disorders Autonomic dysfunction Muscle strength training Isometric exercise Hemiplegia Heart rate Pressor responses 片麻痺等尺性運動

项目摘要

Although isometric exercise is useful for improvement of muscle strength in unaffected limbs of patients with cerebrovascular accidents (CVA), the pressor responses induced by cardiovascular changes during static exercise in CVA patients are not well defined. We compared the cardiovascular responses to static exercise of elbow flexor muscle between 8 patients with 3-month history of CVA who had documented damage of subcortical structures and 8 control men. Changes in heart rate (HR), arterial blood pressure (BP) and muscle sympathetic nerve activity (MSNA), recorded from the peroneal nerve on the affected side, were determined before, during and after a 2-min sustained contraction of elbow flexor muscles at 35% maximal voluntary contraction. During the control period, the mean burst count of MSNA in CVA patients (64.5±5.0 beats/100HR) was higher than in control subjects (43.5±7.1 beats/100HR) (P<K 0.05). Total MSNA (the mean burst amplitude per minute times burst rate) increased significantly in CVA and control during static exercise by 18.7±6.3% and 95.8±25.2%, respectively. The percent changes in total MSNA, HR and MBP in CVA patients were attenuated during static exercise, compared with the control subjects. Our results indicated the presence of intact pressor responses during static exercise in CVA patients although the magnitudes of such responses were attenuated relative to the control. Therefore, damage of subcortical structures might be involved in lowering the pressor response during exercise. Our results indicate that static exercise does not put patients with CVA at risk of marked increases in HR and BP.

虽然等长运动有助于改善脑血管意外(CVA)患者健侧肢体的肌力，但CVA患者在静态运动过程中心血管变化引起的升压反应尚不清楚。我们比较了8名有3个月病史、有皮质下结构损害的CVA患者和8名对照组的肘屈肌对静态运动的心血管反应。记录患侧腓神经记录的心率(HR)、动脉血压(BP)和肌交感神经活动(MSNA)的变化，在肘屈肌以35%的最大自主收缩持续收缩2min之前、期间和之后进行测定。对照组MSNA平均爆发次数(64.5±5.0次/100HR)明显高于对照组(43.5±7.1次/100HR)(P&lt；K0.05)。总MSNA(每分钟平均爆发幅度×爆发频率)在安静运动中，CVA组和对照组分别增加18.7±6.3%和95.8±25.2%。CVA患者的MSNA、HR和MBP在静态运动中的百分比变化较对照组有所减弱。我们的结果表明，CVA患者在静态运动过程中存在完整的升压反应，尽管这种反应的幅度相对于对照组有所减弱。因此，皮质下结构的损伤可能与运动中降低升压反应有关。我们的结果表明，静态运动不会使CVA患者面临心率和血压显著增加的风险。