Head-out immersion in hot water increases serum levels of IL-6.

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We hypothesized that head-out hot water immersion (heat stress) increases serum IL-6 in human. Each of 8 healthy adults performed 6 different tests of 30-min rest/20-min intervention/60-min recovery, including rest in air (RA, room temperature 28C), rest during thermoneutral (35.5C) water immersion (RIN), rest during hot (42.0C) water immersion (RIH), exercise in air (EA, ergometer exercise at 60% of VO2max), exercise during thermoneutral water immersion (EIN), and exercise during hot water immersion (EIH). RIH and EIH increased core temperature during and after the immersion and serum levels of IL-6 at recovery period, and the increase in IL-6 level was greater than in RA and RIN. Exercise did not significantly increase IL-6 in EA and EIN. EIH markedly increased IL-6, although the magnitude of the increase was not significantly higher than RIH. These findings demonstrated that hot water immersion increases serum IL-6 through increased body core temperature.