An Epidemiologic Study on an Excess Risk of Lung Cancer in the Southeast Area of Okayama Prefecture, Japan

日本冈山县东南部地区肺癌超额风险的流行病学研究

• 批准号: 08670393
• 负责人: TSUDA Toshihide
• 金额: $ 1.54万
• 依托单位: Okayama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08670393/
• 关键词: Epidemiology; Population-based; Case-control study; Cancer control; Silica; Silicosis; Lung cancer; Refractory brick production; シリカ暴露; じん肺; 肝癌; 大腸癌; じん肺の胸部X線所見; 粉じん曝露; その他の癌; メタアナリシス; 郵送調査

In the south east of Okayama Prefecture, Japan, there have been reports on high prevalence of silicosis among refractory brick production workers, and excess risk of lung cancer among the residents. Therefore, a population based case-control study was conducted on the relationship between silica, silicosis, and lung cancer.Cases and controls were restricted to male subjects and obtained from death certificates from 1986 to 1993 in the area. Four kinds of deceased control groups were selected ; the series of deaths from liver cancer, colon cancer, and cancers of the other organs, which assumed not to be related to silica exposure. Age and smoking habits were adjusted by stratified analysis using the Mantel-Haenszel odds ratio estimates. Unconditional logistic regression analysis was also conducted for controlling potential confounding factors ; such as age and smoking habits.The age-, smoking-adjusted odds ratios were 1.59 (0.87-3.03) for liver cancer control, 1.94 (0.94-4.43) for colon … More cancer control, and 2.13 (1.19-3.85) for the other cancer control on silica exposure, and 2.45 (1.22-5.34), 2.94 (1.30-8.90), and 2.69 (1.43-5.37) on silicosis, respectively. Histologic or cytologic types of lung cancer cases were obtained from 64.1% (118/184). On histologic types of lung cancer, small cell carcinoma may related to silica exposure after comparing with unexposed lung cancer cases and the data from the general Japanese population. On the findings of chest X-ray, elevated lung cancer mortality compared with other cancers than lung was demonstrated among the patients without large opacities.Silica exposure increased the lung cancer mortality in the area. The results support the causal relationship between silica exposure and lung cancer, designated by IARC in 1997. From now, the relationship between silica exposure and esophagus cancer, gastric cancer, liver cancer. and hematopoietic malignancy which has been reported the association to silica exposure should be investigated and examined. Less

在日本冈山县东南部，有关于耐火砖生产工人中硅肺高患病率和居民中肺癌高风险的报道。因此，我们进行了一项以人群为基础的病例对照研究，以研究矽尘、矽肺和肺癌之间的关系，病例和对照仅限于男性受试者，并从该地区1986年至1993年的死亡证明中获得。选择了四种死亡对照组;肝癌、结肠癌和其他器官癌症的死亡系列，假定与二氧化硅暴露无关。使用Mantel-Haenszel比值比估计值通过分层分析调整年龄和吸烟习惯。控制了年龄和吸烟习惯等潜在混杂因素后，进行非条件Logistic回归分析，年龄和吸烟调整后的OR值分别为：肝癌控制1.59（0.87-3.03），结肠癌1.94（0.94-4.43 ...更多信息 矽尘暴露组为2.45（1.22-5.34）、2.94（1.30-8.90）和2.69（1.43-5.37）。肺癌组织学或细胞学类型的检出率为64.1%（118/184）。在肺癌的组织学类型方面，与未暴露的肺癌病例和日本普通人群的数据相比，小细胞癌可能与二氧化硅暴露有关。在胸部X线检查中，无大阴影的患者肺癌死亡率高于其他癌症，二氧化硅暴露增加了该地区的肺癌死亡率。结果支持IARC在1997年指定的二氧化硅暴露与肺癌之间的因果关系。从目前来看，矽尘暴露与食道癌、胃癌、肝癌的关系。和造血系统恶性肿瘤，其中已报告的关联二氧化硅暴露应进行调查和检查。少

项目成果

津田敏秀: "疫学から見た作業関連性疾患と職業病 : 再論" 産業衛生学雑誌. 40(3). A52-A55 (1998)

Toshihide Tsuda：“从流行病学角度看与工作有关的疾病和职业病：重新审视”《工业卫生杂志》40(3) (1998)。

津田敏秀: "じん肺患者における肺がんの多発-メタアナリシスの試み-" 産業衛生学雑誌. 38(2). 70-71 (1996)

Toshihide Tsuda：“尘肺病患者肺癌发病率高——荟萃分析的尝试”《工业卫生杂志》38(2) (1996)。

Toshihide Tsuda: "A Meta-Analysis on the Relationship between Pneumoconiosis and Lung Cancer" Journal of Occupational Health. 39(4). 285-294 (1997)

Toshihide Tsuda：“尘肺病与肺癌关系的荟萃分析”职业健康杂志。

Toshihide Tsuda: "Lung Cancer Mortality among Pneumoconiosis Patients--A Meta-Analysis--" Japanese Journal of Industrial Health. 38-2. 70-71 (1996)

Toshihide Tsuda：“尘肺病患者肺癌死亡率——荟萃分析——”日本工业健康杂志。

津田敏秀: "医学における因果関係の推論-疫学での歴史的流れ-" 日本衛生学雑誌. 51(2). 558-568 (1996)

Toshihide Tsuda：“医学因果关系的推论 - 流行病学的历史趋势”日本卫生杂志 51(2) 558-568 (1996)。