Epidemiological study of EBV-associated gastric carcinoma

EBV相关胃癌流行病学研究

• 批准号: 08670442
• 负责人: AKIBA Suminori
• 金额: $ 1.47万
• 依托单位: Kagoshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08670442/
• 关键词: EBV; Gastric carcinoma; smoking; birth order; epidemiology; ケースコントロール研究; 食習慣

To clarify the difference of environmental factors between Epstein-Barr virus (EBV) positive and negative gastric carcinoma cases, we conducted a questionnaire survey in Kagoshima Prefecture, Japan, from 1996 to 1997. The subjects in the present study were 28 EBV-positive and 60 EBV-negative gastric carcinoma cases. For each EBV-positive case, 2 EBV-negative cases in males and 3 EBV-negative cases in females were matched by sex and age (+/- 5 years old). All subjects were asked the number of siblings, birth order, smoking and drinking habit, intake of beverages, other dietary factors, and occupation. We analyzed the data in the logistic regression models.We found that the birth order or the duration of smoking habit were associated with the risk of EBV-associated gastric carcinoma. The odds ratio (OR) for EBV-positive cases was reduced among persons of late birth order. The risk among persons with five or more siblings was nearly half that among those with four or less, but the ORs were not statistically significant. The OR among persons who have smoked more than 40 years was 6.1 in comparison with persons who have smoked less than 20 year or never smoked. However, the prevalence of smokers/ex-smokers and the dose of cigarettes were not associated with the risk of EBV-positive cases.The findings in the present study indicated that the age at EBV-infection might be related to the development of EBV-associated gastric carcinoma.

为了明确EB病毒（EBV）阳性和阴性胃癌病例环境因素的差异，我们于1996年至1997年在日本鹿儿岛县进行了问卷调查。本研究的受试者为28例EBV阳性和60例EBV阴性胃癌病例。对于每个 EBV 阳性病例，男性 2 例 EBV 阴性病例和女性 3 例 EBV 阴性病例按性别和年龄（+/- 5 岁）进行匹配。所有受试者都被询问兄弟姐妹的数量、出生顺序、吸烟和饮酒习惯、饮料摄入量、其他饮食因素和职业。我们分析了逻辑回归模型中的数据。我们发现出生顺序或吸烟习惯的持续时间与 EBV 相关胃癌的风险相关。晚出生者中 EBV 阳性病例的比值比 (OR) 降低。有五个或更多兄弟姐妹的人的风险几乎是有四个或更少兄弟姐妹的人的一半，但 OR 并不具有统计学意义。吸烟年限超过 40 年的人与吸烟年限不足 20 年或从不吸烟的人相比，OR 为 6.1。然而，吸烟者/戒烟者的患病率和香烟剂量与 EBV 阳性病例的风险无关。本研究的结果表明，EBV 感染年龄可能与 EBV 相关胃癌的发生有关。

项目成果

秋葉澄伯: "EBウイルス関連胃がんとHLA" 日本臨床. 55・2. 116-120 (1997)

秋叶纯明：“EB病毒相关胃癌和HLA”日本临床杂志55・2（1997）。

秋葉 澄伯: "EBウイルス関連胃がんとHLA" 日本臨床. 55・2. 116-120 (1997)

Sumihaku Akiba：“EB病毒相关胃癌和HLA”日本临床杂志55・2（1997）。