Epidemiological study of HPV-related cancers in Asia-Pacific region

亚太地区HPV相关癌症流行病学研究

• 批准号: 17015037
• 负责人: AKIBA Suminori
• 金额: $ 33.41万
• 依托单位: Kagoshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17015037/
• 关键词: 疫学; 癌; ウイルス; 環境要因; 遺伝的背景; がん

Detection of human papillomavirus (HPV), a widely-accepted risk factor of cervical cancer, has been reported in other types of carcinomas including cancers of the esophagus and the lung. To clarify the effects of interactions among environmental factors including radiation exposure and lifestyles, viral factors, and genetic factors on carcinogenesis, this study examine epidemiological, clinic-pathological, viral, and molecular biological features of virus (mainly HPV)-related cancers in comparison with those of non-virus-related cancers.HPV genome was detected in 10-30% of carcinomas of the esophagus, the lung, and the breast, and its detection rate varied by regions and histological type of tumors. The most frequent genotype was high-risk type of HPV-16 in all sites of tumors. Although real-time PCR analysis indicated the presence of integrated-form of viral DNA in most of HPV-16-positive specimens, the estimated viral load was significantly lower (around 0.1 copy per cell) than that of cervical cancers. These results suggested that the role of HPV in carcinogenesis differ between these organs and cervix.On the other hand, we observed the high frequency of HPV-positive cases among gefitinib-responsive lung adenocarcinomas, and the high frequency of high-risk types of HPV and high viral load in cancers in a high background radiation area. Further investigations are warranted to examine HPV interactions with genetic and other environmental factors.

人乳头瘤病毒(HPV)是一种被广泛接受的宫颈癌危险因素，据报道，在其他类型的癌症中也有检测到HPV，包括食道癌和肺癌。为了阐明辐射暴露和生活方式、病毒因素和遗传因素之间的相互作用对肿瘤发生的影响，本研究比较了与病毒(主要是HPV)相关的癌症的流行病学、临床病理、病毒和分子生物学特征。在10%-30%的食道癌、肺癌和乳腺癌中检测到HPV基因组，其检出率因肿瘤的区域和组织类型而异。在所有肿瘤部位中，最常见的基因型是高危型HPV-16。虽然实时聚合酶链式反应分析表明，在大多数HPV-16阳性的样本中存在整合形式的病毒DNA，但估计的病毒载量(每个细胞约0.1个拷贝)明显低于宫颈癌。这些结果表明，HPV在这些器官和宫颈的致癌作用不同。另一方面，我们观察到吉非替尼敏感的肺腺癌中HPV阳性病例的高频率，以及高本底辐射地区癌症中高危类型HPV和高病毒载量的高频率。有必要进行进一步的研究，以检查HPV与遗传和其他环境因素的相互作用。

项目成果

Human papillomavirus in high- and low-risk areas of oesophageal squamous cell carcinoma in China.

中国食管鳞状细胞癌的高风险区域中的人乳头瘤病毒。

• DOI: 10.1038/sj.bjc.6603765
• 发表时间: 2007-05-21
• 期刊: BRITISH JOURNAL OF CANCER
• 影响因子: 8.8
• 作者: Shuyama, K;Castillo, A;Aguayo, F;Sun, Q;Khan, N;Koriyama, C;Akiba, S
• 通讯作者: Akiba, S

Human papillomavirus in lung carcinomas among three Latin American countries.

三个拉丁美洲国家肺癌中的人乳头瘤病毒。

• 发表时间: 2006
• 期刊: Oncology Reports. 15(4)
• 作者: Castillo A;Aguayo F;Koriyama C;Shuyama K;Akiba S;Herrera-Goepfert R;Carrascal E;Klinge G;Sanchez J;Eizuru Y.
• 通讯作者: Eizuru Y.

Human papillomavirus in lung carcinomas among three Latin American countries

三个拉丁美洲国家肺癌中的人乳头瘤病毒

• 发表时间: 2006
• 期刊: Oncology Reports 15・4
• 作者: Corvalan A;Ding S;Koriyama C;Carrascal E;Carrasquilla G;Backhouse C;Urzua L;Argandona J;Palma M;Eizuru Y;Akiba S.;荒木令江;Castillo A. et al.
• 通讯作者: Castillo A. et al.

Nasal NK/T-cell lymphoma and its association with type i/Xhol loss strain Epstein-Barr virus in Chile

智利鼻 NK/T 细胞淋巴瘤及其与 i/Xhol 丢失株 Epstein-Barr 病毒的关联

• 发表时间: 2006
• 期刊: Journal of Clinical Pathology
• 影响因子: 3.4
• 作者: Corvalan A;Ding S;Koriyama C;Carrascal E;Carrasquilla G;Backhouse C;Urzua L;Argandona J;Palma M;Eizuru Y;Akiba S.;荒木令江;Castillo A. et al.;荒木令江;Corvalan A. et al.;荒木令江;Castillo A. et al.;Cabrera ME. et al.
• 通讯作者: Cabrera ME. et al.

Epstein-Barr virus detection in tumors of upper gastrointestinal tract. An in situ hybridization study in Pakistan

上消化道肿瘤中 Epstein-Barr 病毒的检测。

• 发表时间: 2005
• 期刊: Journal of Experimental & Clinical Cancer Research 24・3
• 作者: Corvalan A;Ding S;Koriyama C;Carrascal E;Carrasquilla G;Backhouse C;Urzua L;Argandona J;Palma M;Eizuru Y;Akiba S.;荒木令江;Castillo A. et al.;荒木令江;Corvalan A. et al.;荒木令江;Castillo A. et al.;Cabrera ME. et al.;荒木令江;Tabata H. et al.;荒木令江;Campos F. et al.;荒木令江;Campos F. et al.;荒木令江;Marugame T. et al.;Yoshiwara E. et al.;荒木 令江;荒木令江 編集;Anwar M. et al.
• 通讯作者: Anwar M. et al.