Mechanism of acute coronary syndrome and local delivery therapy

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This study was designed to clarify the pathogenesis of acute coronary syndrome(ACS) and to evaluate the efficacy of local treatment of thrombosis with various antithrombotic drugs using our novel porous balloon catheter. In patients with ACS, CD63 antigen and chemise was expressed at vascular smooth muscle cell (VSMC) of fresh atherosclerotic plaque. On the other hand, these molecules were not detected in the plaque of stable angina. Experimental study demonstrated that local delivery of antithrombin using a novel porous balloon catheter could prevent thrombus formation in injured atherosclerotic arteries without significant influence on systemic coagulability. In patients with ACS, local delivery of antithrombin or t-PA could prevent thrombus formation after PTCA and could induce thrombolysis.