Studise on prolactin(PRL)secretion of premature and full-term neonates in normal and various pathological conditions.

早产儿和足月新生儿正常及各种病理状态下催乳素（PRL）分泌的研究。

• 批准号: 08670921
• 负责人: TAKAHASHI Hiroaki
• 金额: $ 0.64万
• 依托单位: Kanazawa Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08670921/
• 关键词: prolactin; perinatal period; seizures in children; Thyrotropin releasing hormone (TRH); Thyrotropin releasing hormone (TRH)

In 1993, we studied prolactin secretion of premature and normal newborns in perinatal period. Since 1996, we have studied prolactin secretion of small-for date, appropriate-for date and large-fo-date newborns in increased number. We have also studied prolactin secretion of children with various central nervous system disorders, i.e. intracranial hemorrhage, purulent meningitis, febrile seizure, West syndrome, epilepsy and periodic ACTH-ADH discharge syndrome. In prematurenewborns born between 28 and 37 weeks of gestation, serum prolactin increased with increasing gestational weeks and reached at highest level in full-term normal neonates. There were no significant difference of serum prolactin between small-for-date, appropriate-for date and large-for date newborns and role prolactin as growth factor was not proved. In asphyxia of full-term neonates, prolactin levels were high and stayd high for longer period, however in asphyxia of premature neonates, prolactin did not show significant difference from premature neonates without asphyxia, probably due to immature development of prolactin inhibiting effect of hypothalamus. In intracranial hemorrhage and purulent meningitis neonates, high serum prolactin were observed in serious cases.In seizure disorders, serum prolactin increased during attacks and returned to normal between attacks.

1993年我们对早产儿和正常新生儿围产期催乳素分泌进行了研究。自1996年以来，我们研究了越来越多的小胎、适胎和大胎新生儿的催乳素分泌。我们还研究了各种中枢神经系统疾病，即颅内出血，化脓性脑膜炎，热性惊厥，西方综合征，癫痫和周期性ACTH-ADH分泌综合征的儿童催乳素分泌。孕28 ~ 37周早产儿血清催乳素随孕周增加而升高，足月正常新生儿血清催乳素水平最高。小胎、适胎和大胎新生儿血清催乳素水平无显著性差异，催乳素作为生长因子的作用尚不明确。足月新生儿窒息时催乳素水平较高，且持续时间较长，而早产儿窒息时催乳素水平与未窒息早产儿相比无显著性差异，可能与下丘脑催乳素抑制作用的发育不成熟有关。新生儿颅内出血和化脓性脑膜炎严重时血清催乳素升高，癫痫发作时血清催乳素升高，发作间期恢复正常。

项目成果

近藤 裕成, 高橋 弘昭 他: "新生児期におけるプロラクチンの動態と分泌に関する研究" 金沢医科大学雑誌. 17. 267-274 (1992)

Hironari Kondo、Hiroaki Takahashi 等：“新生儿期催乳素动态和分泌的研究”金泽医科大学学报 17. 267-274 (1992)。