Studise on prolactin(PRL)secretion of premature and full-term neonates in normal and various pathological conditions.

点击翻译按钮获取中文摘要

In 1993, we studied prolactin secretion of premature and normal newborns in perinatal period. Since 1996, we have studied prolactin secretion of small-for date, appropriate-for date and large-fo-date newborns in increased number. We have also studied prolactin secretion of children with various central nervous system disorders, i.e. intracranial hemorrhage, purulent meningitis, febrile seizure, West syndrome, epilepsy and periodic ACTH-ADH discharge syndrome. In prematurenewborns born between 28 and 37 weeks of gestation, serum prolactin increased with increasing gestational weeks and reached at highest level in full-term normal neonates. There were no significant difference of serum prolactin between small-for-date, appropriate-for date and large-for date newborns and role prolactin as growth factor was not proved. In asphyxia of full-term neonates, prolactin levels were high and stayd high for longer period, however in asphyxia of premature neonates, prolactin did not show significant difference from premature neonates without asphyxia, probably due to immature development of prolactin inhibiting effect of hypothalamus. In intracranial hemorrhage and purulent meningitis neonates, high serum prolactin were observed in serious cases.In seizure disorders, serum prolactin increased during attacks and returned to normal between attacks.