Neurophysiological reward responsiveness, stress, and depressive symptoms across the perinatal period

整个围产期的神经生理奖赏反应、压力和抑郁症状

• 批准号: 10669099
• 负责人: Samantha Pegg
• 金额: $ 3.17万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10669099
• 关键词: Adolescent; Adult; Animals; Antidepressive Agents; Award; Biological; Child; Childbirth; Clinical; Clinical Research; Cognitive; Complex; Data; Data Collection; Development; Diagnostic; Dorsal; Electroencephalography; Emotional; Estrogens; Event-Related Potentials; Feedback; Fellowship; Frequencies; Goals; Grant; Grooming; Hormones; Hydrocortisone; Impairment; Infant; Intervention; Interview; Knowledge; Life Stress; Link; Literature; Longitudinal Studies; Maintenance; Maternal Behavior; Measures; Mental Depression; Methods; Modeling; Mood Disorders; Mothers; Neurobiology; Neurosciences; Neurosciences Research; Outcome; Participant; Pathway interactions; Patient Self-Report; Pattern; Perinatal; Postpartum Depression; Postpartum Period; Pregnancy; Pregnant Women; Prevention; Process; Productivity; Progesterone; Research; Research Project Grants; Research Support; Research Training; Rewards; Risk; Risk Factors; Safety; Sampling; Scientist; Second Pregnancy Trimester; Social Impacts; Statistical Methods; Stress; Stress Tests; System; Testing; Third Pregnancy Trimester; Time; Training; Training Support; Ventral Striatum; Visit; Woman; Work; antepartum depression; barrier to care; career; depressive symptoms; experience; feeding; financial incentive; functional disability; high risk; innovation; neural; neuroimaging; neurophysiology; offspring; perinatal period; peripartum depression; pre-doctoral; preventive intervention; prospective; research study; response; skills; social; social stigma; stress symptom; suicidal risk

PROJECT SUMMARY/ABSTRACT Perinatal depression (i.e., depression during pregnancy and following childbirth) is a prevalent and debilitating condition that is associated with significant impairments in maternal functioning and negative impacts on offspring, making the identification of targets for prevention critically needed. Neuroscience research outside of the perinatal period has shown a prospective association between reduced neural reward responsiveness and depression, but the extent to which depression further alters reward responsiveness has yet to be examined. The perinatal period presents a unique time of adaptations of the reward system which have implications for the development of depression, but neuroscience research has primarily been limited to the postpartum period due to concerns about the safety of neuroimaging during pregnancy. Stress has been shown both to reduce reward responsiveness and moderate effects of low reward responsiveness on depression, adding further complexity to pathways to depression across time. Given the added stress and unique biological changes associated with reward system adaptations, longitudinal work is needed to understand pathways through which women develop perinatal depression. As part of a larger project, this research study will use safe and temporally sensitive methods to measure neural reward responsiveness, stress, and depressive symptoms in 100 pregnant women at 20 weeks gestation, 34 weeks gestation, and 8 weeks postpartum. At each assessment, participants will complete a monetary incentive delay task while electroencephalogram is recorded in response to reward and loss feedback. Event-related potential (e.g., the reward positivity, a reliable time-domain measure of initial reward responsiveness) and time-frequency data (i.e., delta and theta activity, frequency-domain markers of sensitivity to rewards and negative outcomes, respectively) will be used to measure neurophysiological response to reward. Participants will complete self-report and interview measures of depressive symptoms and stress at each visit. Through the longitudinal collection of these data, the present research will examine longitudinal associations between reduced reward responsiveness and depression using an innovative bidirectional model to tease apart directionality of these associations across time (Specific Aim 1). This work will also test stress as a moderator of the associations between reward responsiveness and depressive symptoms across the perinatal period (Specific Aim 2). This predoctoral fellowship award will bring together a team of experts in their respective fields and allow for advanced training in life stress assessment, perinatal depression and risk, EEG time-frequency analysis, and quantitative methods. Together, the research project and training will provide the fellow the opportunity to develop necessary skills for a productive career as a clinical scientist investigating alterations in emotional and social processing and how these processes contribute to the development of mood disorders to inform intervention.

项目摘要/摘要 围产期抑郁(即怀孕期间和分娩后的抑郁)是一种普遍的、使人虚弱的疾病 与产妇功能严重受损有关的状况，并对 子孙后代，因此迫切需要确定预防目标。国外的神经科学研究 围产期已显示神经奖赏反应性降低和 抑郁，但抑郁在多大程度上进一步改变奖赏反应还有待研究。 围产期出现了奖励制度的独特适应时间，这意味着 抑郁症的发展，但神经科学的研究主要局限于产后时期 出于对怀孕期间神经成像安全性的担忧。压力已经被证明既能减少压力 奖赏反应性和低奖赏反应性对抑郁的中等效应，进一步增加 随着时间的推移，抑郁的路径变得复杂。考虑到额外的压力和独特的生物变化 与奖励系统的适应相关，需要纵向工作来理解通过什么途径 女性会患上围产期抑郁症。作为一个更大项目的一部分，这项研究将使用SAFE和 时间敏感的方法测量神经奖赏反应、压力和抑郁症状 100名孕妇分别在孕期20周、孕期34周和产后8周。在每个 评估时，参与者将完成一项货币激励延迟任务，而脑电则 为响应奖励和损失反馈而录制。事件相关电位(例如，奖励的积极性、可靠的 初始奖励响应性的时间域测量)和时间-频率数据(即，增量和θ活动， 分别对奖励和负面结果敏感的频域标记)将用于 测量对奖励的神经生理反应。参与者将完成自我报告和面试测量 每次就诊时的抑郁症状和压力。通过对这些数据的纵向收集，目前 研究将检验奖励反应性降低和抑郁之间的纵向联系 一个创新的双向模型来梳理这些关联随时间变化的方向性(特定目标 1)。这项工作还将测试压力，作为奖励反应和奖励反应之间关系的调节变量 整个围产期的抑郁症状(具体目标2)。这项博士后奖学金将为您带来 汇集各自领域的专家团队，允许接受生活压力评估方面的高级培训， 围产期抑郁与风险，脑电时频分析，定量方法。总之，这项研究 项目和培训将为研究员提供机会发展必要的技能，以实现富有成效的职业生涯，如 一位临床科学家研究情绪和社交过程中的变化，以及这些过程是如何 有助于情绪障碍的发展，通知干预。

项目成果

Behavioral and psychiatric correlates of brain responses to social feedback.

大脑对社会反馈的反应的行为和精神相关性。

• DOI: 10.1111/psyp.14413
• 发表时间: 2024
• 期刊: Psychophysiology
• 影响因子: 3.7
• 作者: Rappaport,BrentI;Kujawa,Autumn;Arfer,KodiB;Pegg,Samantha;Kelly,Danielle;Jackson,JoshuaJ;Luby,JoanL;Barch,DeannaM
• 通讯作者: Barch,DeannaM