EFFECT OF slgA AND IGF-1 ON BILE DUCT REGENERATION FOLLOWING HEPATECTOMY

slgA 和 IGF-1 对肝切除术后胆管再生的影响

• 批准号: 08671485
• 负责人: FUJITA Tetsuji
• 金额: $ 1.28万
• 依托单位: JIKEI UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08671485/
• 关键词: Secretory lgA; Bile Duct Growth; Interleukin-6; 分科型IgA; 胆道再生; 胆道閉鎖; 胆道

Although we examined the efffects of secretory immunoglobulin A (slgA) and insulin-like growth factor 1 (IGF-1) on bile duct regeneration after partial hepatectomy in rats, we failed to show the beneficial influences of intraperitoneal administration of slgA or IGF-1 on rat bile duct regeneration.Following the experimental study, we investigated whether circulating sIgA levels correlate with cytokine levels in the systemic or portal circulation during major abdominal surgery. Twenty patients who underwent abdominal surgery for malignant carcinoma were included in the study. Portal blood samples were taken for the measurements of cytokine levels during abdominal surgery. Systemic blood samples were simultaneously collected for the determination of cytokine and sIgA levels. Postoperative laboratory protocol included routine liver function tests and serum slgA levels.Circulating sIgA levels correlated with interleukin-6 levels (r=0.48, P<0.05) in the portal circulation. In the postoperative period, the best correlation between sIgA and other biochemical parameters was found with alkaline phosphatase (r=0.87, P<0.01), followed by alanine aminotransferase (r=0.70, P<0.01)lnterleukin-6 in the portal circulation might stimulate synthesis of sIgA.It could be proposed that sIgA may possibly function as bile duct growth factor.

虽然我们研究了分泌型免疫球蛋白A（sIgA）和胰岛素样生长因子1（IGF-1）对大鼠肝部分切除后胆管再生的影响，但我们未能显示腹腔内施用sIgA或IGF-1对大鼠胆管再生的有益影响。我们研究了在腹部大手术期间循环sIgA水平是否与体循环或门静脉循环中的细胞因子水平相关。本研究纳入了20例因恶性肿瘤接受腹部手术的患者。在腹部手术期间采集门静脉血样品用于测量细胞因子水平。同时收集全身血液样品用于测定细胞因子和sIgA水平。术后常规肝功能检查及血清sIgA水平，门脉循环sIgA水平与IL-6水平呈显著正相关（r=0.48，P<0.05）。术后sIgA与其他生化指标相关性最好的是碱性磷酸酶（r=0.87，P<0.01），其次是丙氨酸氨基转移酶（r=0.70，P<0.01）。门脉循环中的IL-6可能刺激sIgA的合成，提示sIgA可能具有胆管生长因子的作用。

项目成果

Tetsuji Fujita,et al.: "Relationship between Circulating Secretory Immunoglobulin A Levels and Portal Blood Cytokine Levels during Major Abdominal Surgery" Archives of Surgery. 132. 124-128 (1997)

Tetsuji Fujita 等人：“大型腹部手术期间循环分泌性免疫球蛋白 A 水平与门静脉血细胞因子水平之间的关系”手术档案。

Tetsuji Fujita, Susumu Kobayashi, Tomoyuki Saeki, Kihachiro Itsubo: "Relationship Between Circulating Secretory Immunoglobulin A Levels and Portal Blood Cytokine Levels During Major Abdominal Surgery." Arch Surg. 132. 124-127 (1997)

Tetsuji Fujita、Susumu Kobayashi、Tomoyuki Saeki、Kihachiro Itsubo：“腹部大手术期间循环分泌性免疫球蛋白 A 水平与门静脉血细胞因子水平之间的关系。”