Autocrine/Paracrine Regulation of Intrahepatic Bile Duct Growth

肝内胆管生长的自分泌/旁分泌调节

• 批准号: 7921540
• 负责人: Gianfranco D Alpini
• 金额: --
• 依托单位: OLIN TEAGUE VETERANS CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-10-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7921540
• 关键词: Acute; Address; Adenylate Cyclase; Alcoholic Liver Cirrhosis; Alcohols; American; Animals; Apoptosis; Apoptotic; Bicarbonates; Bile fluid; Biliary; Biochemical; CREB1 gene; Calcium/calmodulin-dependent protein kinase; Carbon Tetrachloride; Cells; Cessation of life; Cholangiocarcinoma; Cholestasis; Chronic; Cirrhosis; Clinic; Complex; Coupled; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cystic Fibrosis Transmembrane Conductance Regulator; Data; Diffuse; Down-Regulation; Duct (organ) structure; Ductal; Duodenum; ELK1 gene; Equilibrium; Evaluation; Extrahepatic Cholestasis; Functional disorder; Gastrointestinal Hormones; Gene Expression; Gene-Modified; Genes; Growth; Health; Hepatitis Viruses; Hepatocyte; Hormones; Hospitalization; Human; Human Cell Line; Hyperplasia; Immunohistochemistry; In Situ; In Vitro; Incidence; Inflammation; Inflammatory; Injury; Injury to Liver; Intrahepatic bile duct; Italy; Laboratories; Lead; Letters; Ligation; Liver; Liver Cirrhosis; Liver diseases; MAPK3 gene; Measures; Modeling; Molecular; Morbidity - disease rate; Mus; Nature; Pathologic Processes; Pathway interactions; Patients; Pharmaceutical Preparations; Phenotype; Play; Primary biliary cirrhosis; Primary carcinoma of the liver cells; Process; Proliferating; Protein Isoforms; Proteins; Reaction; Receptor Activation; Receptor Up-Regulation; Regulation; Resistance; Rodent; Role; Rome; S Cells (Intestine); SCTR gene; SP1 gene; Sampling; Secretin; Serum; Signal Pathway; Signal Transduction; Signal Transduction Pathway; Staging; Structure; Testing; Time; Toxin; Transcriptional Activation; United States Department of Veterans Affairs; Universities; Up-Regulation; Vascular Endothelial Cell; Veterans; Wild Type Mouse; Work; autocrine; bile duct; biliary tract; cell type; cholangiocyte; design; gastrointestinal; high risk; in vivo; indexing; inhibitor/antagonist; intrahepatic; liver transplantation; mortality; mouse model; novel; novel therapeutic intervention; novel therapeutics; paracrine; population based; prevent; primary sclerosing cholangitis; promoter; receptor; receptor expression; research study; response; secretin receptor; small hairpin RNA; therapeutic development; tool; trait; treatment strategy