Chemoprevention of hamster pancreatic carcinogenesis

仓鼠胰腺癌的化学预防

• 批准号: 08671497
• 负责人: IWAMOTO Sueharu
• 金额: $ 1.22万
• 依托单位: KAWASAKI MEDICAL SCHOOL
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08671497/
• 关键词: pancreatic carcinogenesis; hamster; chemoprevention; beta-carotene; palm carotene; green tea polyphenol; alpha-carotene; αカロチン

The effect of alpha-carotene, beta-carotene, palm carotene and green tea polyphenols (GTP) on the progression stage of pancreatic carcinogenesis after rapid production of ductal lesions were studied in Syrian hamsters. Dose threshold inhibitory effects were noted for beta-carotene, 25 ppm and palm caratene, 40 ppm which includes 25 ppm beta-carotene reducing the numbers of putative preneoplastic lesions of duct epithelial hyperplasia, atypical hyperplasia, as well as carcinoma in situ and invasive carcinomas. GTP at deses of 500 and 5000 ppm, but not 100 ppm, also significantly decreased the numbers of hyperplasia and total duct lesions. Combined administration of 40 ppm palm carotene and 50 ppm GTP similarly inhibited the lesion development. alpha-Carotene, however, did not affect pancreatic carcinogenesis. These results suggest that chemopreventive effects are exerted by beta-carotene and GTP above critical doses and that combined administration of palm carotene and GTP might be a candidate chemoprevention strategy for pancreatic cancer in man.

在叙利亚仓鼠中研究了α-胡萝卜素、β-胡萝卜素、棕榈胡萝卜素和绿色茶多酚（GTP）对胰腺癌发生的进展阶段的作用，所述胰腺癌发生在快速产生导管损伤之后。观察到25 ppm β-胡萝卜素和40 ppm棕榈胡萝卜素（包括25 ppm β-胡萝卜素）的剂量阈值抑制作用，可减少导管上皮增生、非典型增生以及原位癌和浸润性癌的推定癌前病变数量。浓度为500和5000 ppm（但不是100 ppm）的GTP也显着减少增生和总导管病变的数量。40 ppm棕榈胡萝卜素和50 ppm GTP的联合给药同样抑制了病变的发展。然而，α-胡萝卜素并不影响胰腺癌的发生。这些结果表明，β-胡萝卜素和GTP施加的化学预防作用超过临界剂量，棕榈胡萝卜素和GTP的联合给药可能是一个候选的胰腺癌的化学预防策略。

项目成果

岩本 末治: "膵頭部膵管内乳頭腺癌に対する幽門輪温存膵頭十二指腸切除術" 消化器外科. 19・5. 529-537 (1996)

Sueharu Iwamoto：“保留幽门环的胰十二指肠切除术治疗胰头和胰管中的乳头状腺癌”19・5（1996）。

伊木 勝道: "孤立性小腸転移を来した黒色腫の1例" 日臨外医会誌. 58・2. 415-418 (1997)

Katsumichi Iki：“孤立性小肠转移的黑色素瘤一例”日本门诊学会杂志 58・2（1997 年）。

S.Iwamoto, M.Kimoto, T.Tsunoda: "Pylorus-preserving pancreatoduodenectomy for intraductal papillary adenocarcinoma of the head of the pancreas. (in Japanese)" Gastroenterological Surgery. 19(5). 529-537 (1996)

S.Iwamoto、M.Kimoto、T.Tsunoda：“保留幽门的胰十二指肠切除术治疗胰头导管内乳头状腺癌。（日语）”胃肠外科。

T.Tsunoda, Y.Yamamoto, M.Kimoto, H.Imai, S.Iwamoto, S.Kawasaki, K.Kawashima, Y.Tadaoka, T.Majima, E.Onuma, K.Iki, T.Kubozoe, T.Eto: "Topics, Staging and treatment for patients with pancreatic cancer. How small is an early pancreatic cancer?" J.Hep.Bil.Pan

T.Tsunoda、Y.Yamamoto、M.Kimoto、H.Imai、S.Iwamoto、S.Kawasaki、K.Kawashima、Y.Tadaoka、T.Majima、E.Onuma、K.Iki、T.Kubozoe、T.

Toshimitsu Majima: "Inhibitory effects of β-carotene, plam carotene, and green tea polyphenols on pancreatic carcinogenesis initiated by N-nitrosobis (2-oxopropyl) amine in Syrian golden hamsters." Pancreas. 16・1. 13-18 (1998)

Toshimitsu Majima：“β-胡萝卜素、棕榈胡萝卜素和绿茶多酚对叙利亚金仓鼠中 N-亚硝基双（2-氧代丙基）胺引发的胰腺癌的抑制作用”13-18。