Investigation for human papillomavirus type-specific cytopathic effect and related epidermoid cysts

点击翻译按钮获取中文摘要

1.In our previous studies, it was revealed that a family of HPVs, HPV4,60 and 65, is associated with not only a specific histologic feature of the homnogeneous intracytoplasmic inclusion bodies but also a characteristic clinical picture of the pigmented warts. In this study we have clearly demonstrated that melanin granules were increased specifically in HPV4/60/65-associated warts, suggesting HPV type-specific pigmentary disorder (Br J Dermatol, 1998). We will attempt immunohistochemical and molecular biological studies to understand the pathomechanism of the HPV type-specific pigmentary disorder in our next year's project.2.HPV 60 is the only virus that has been found in plantar epidermoid cysts. In the present study we have found HPV 57 in a plantar epidermoid cyst which showed a different histological feature from that of HPV 60-associated plantar epidermoid cyst (Br J Dermatol, 1998). We are investigating the relationshop between the epidermoid cysts and HPV 57 in much larger number of plantar epidermoid cysts.Using computor we performed three-dimensional reconstruction analysis for the structure of HPV-associated plantar epidermoid cysts, revealing the fine structure of an epidermoid cyst of eccrine duct origin.