REGIONAL CEREBRAL ACTIVATION STUDY DURING AUDITORY STIMULATION IN PATIENTS WITH COCHLEAR IMPLANTS USING CBF SPECT.

使用 CBF SPECT 对人工耳蜗植入患者进行听觉刺激期间的区域大脑激活研究。

• 批准号: 08671042
• 负责人: JINNOUCHI Seishi
• 金额: $ 1.47万
• 依托单位: Miyazaki Medical College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08671042/
• 关键词: CBF SPECT; cochlear implant; Cerebral activation study; 脳血流; SPECT; 賦活試験

We evaluated a possible change in the regional cerebral blood flow (rCBF) in the auditory areas of the brain during stimulation of a cochlear implant using Tc-99m ECD SPECT.The rCBF was measured during rest (baseline) and during auditory stimulation by presenting simple sound to the ear with the implant (activation) in nine patients in these two years.For baseline study, 370 MBq of Tc-99m ECD was injected at rest and SPECT data were acquired for 20 minutes. Just after the baseline study 740 MBq of ECD was injected during sound stimulation for activation study. Image data were acquired using a three head gamma camera system (PRISM 3000, Picker) with low energy ultra-high resolution fan beam calumniators. SPECT data was subtracted. The change rates of rCBF in various area of the brain were calculated with a formula ; (mean count on activation-mean count on baseline) /baseline*100 (%).We obtained four major points as follows ;1.We could see activation areas in the brain using SPECT.2.Primary auditory areas were activated through a cochlear implant.3.Activation grade was higher in good prognostic patients.4.Right side implantation patients had higher activation and good prognosis.We concluded that CBF SPECT could evaluate the rCBF changes in auditory activation study in patients with cochlear implants. We need more studies in this fields to clarify the auditory cognitive mechanism.

我们用Tc-99 mECDSPECT评价了人工耳蜗刺激时大脑听觉区局部脑血流量（rCBF）的可能变化。（基线）和听觉刺激期间，通过植入物向耳朵提供简单的声音在基线研究中，静息时注射370 MBq的Tc-99 m ECD，并采集20 min的SPECT数据。在基线研究之后，在声刺激期间立即注射740 MBq的ECD用于激活研究。使用具有低能量超高分辨率扇形束校准器的三头伽马照相机系统（PRISM 3000，Picker）获取图像数据。减去SPECT数据。用公式计算各脑区rCBF的变化率;（激活时的平均计数-基线时的平均计数）/基线 *100（%）。1. SPECT检查可见脑内激活区; 2.人工耳蜗植入激活了初级听觉区; 3.预后好的患者激活级别高; 4.右侧植入者激活级别高结论：CBF SPECT可用于评价人工耳蜗植入患者听觉激活的rCBF变化。我们需要更多的研究来阐明听觉认知机制。

项目成果

S.Jinnouchi, S.Nagamachi, H.Nakahara, T.Ohnishi, S.Futami, L.Froles II,K.Watanabe, Y.Ushisako.: "REGIONAL CEREBRAL ACTIVATION DURING AUDITORY STIMULATION IN PATIENTS WITH COCHLEAR IMPLANTS USING Tc-99m ECD SPECT." Europen Jounal of Nuclear Meicined. 23. 1

S.Jinnouchi、S.Nagamachi、H.Nakahara、T.Ohnishi、S.Futami、L.Froles II、K.Watanabe、Y.Ushisako.：“使用 Tc-99m 人工耳蜗植入患者听觉刺激期间的区域大脑激活