Improving Cochlear Implant Outcomes Through Modeling and Programming Strategies Based on Human Inner Ear Pathology
通过基于人类内耳病理学的建模和编程策略改善人工耳蜗的效果
基本信息
- 批准号:10825043
- 负责人:
- 金额:$ 45.35万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-09-18 至 2028-07-31
- 项目状态:未结题
- 来源:
- 关键词:3-DimensionalAcclimatizationAcoustic NerveAction PotentialsAdultAssessment toolAudiologyAuditoryAxonBasic ScienceBehavioralBone GrowthChildChronicClinicalClinical DataCochleaCochlear ImplantsCochlear implant procedureCollectionComplexComputer ModelsDataDetectionDevicesDistantElectric StimulationElectrodesEnvironmentEvoked PotentialsForeign BodiesGoalsGrowthHealthHearingHistologyHistopathologyHumanImplantIndividualKnowledgeLabyrinthLearningMachine LearningMapsMeasuresMethodsModelingNeuronsNoiseOperative Surgical ProceduresOutcomeOutputParticipantPathologyPatientsPatternPerformancePeripheralPhysiologic OssificationPhysiologic pulsePositioning AttributeResearchSpeech PerceptionStimulusTemporal bone structureTestingTimeTranslatingTraumaUpdateVariantclinical careclinical practiceclinical predictorsdensityelectric fieldexperimental studyhearing impairmenthearing restorationimplantationimprovedimproved outcomeinsightnerve supplyneuralneural prosthesisprogramsreconstructionresponsesoundspeech in noisespiral ganglionsuccesstooltranslational approach
项目摘要
Project Summary/Abstract
Cochlear implants are highly successful neural prostheses that enhance or restore hearing to severely
hearing-impaired adults and children. Sound from the environment is converted into electrical pulses and
conveyed to the auditory nerve by an array of electrodes. The cochlear implant provides important spectral and
temporal auditory information to the listener. However, speech perception performance varies considerably
among cochlear implant listeners, particularly in noisy environments and for complex stimuli. A significant
contributing factor to this performance variability is the quality of the electrode-neuron interface, which is defined
by the position of individual electrodes, the relative health and integrity of the neurons and bone and tissue
growth related to trauma from electrode array insertion.
Currently, there is not a clinical tool to query the electrode-neuron interface in cochlear implant listeners,
nor is there an accurate computational model based on human cochlear histopathology to estimate the electrode-
neuron interface. One step towards improving our understanding is to update the classical approach to
quantification of the density and integrity of the auditory neurons in donated human temporal bones from
recipients with cochlear implants. We will harness the power of machine learning to generate 3-D reconstructions
of the neurons relative to the electrodes in the cochlear implant array. To develop clinical measures to predict
variations in the electrode-neuron interface, we will leverage an interdisciplinary team of experts, machine
learning, computational modeling, an unparalleled collection of temporal bones, and a wealth of clinical data.
The long-term goal of the proposed experiments is to improve cochlear implant programming and speech
perception outcomes by improving our understanding of the electrode-neuron interface.
Three aims are proposed: 1) To produce quantitative 3-D maps of cochlear histopathology at the
electrode-neuron interface in temporal bones from cochlear implant recipients and relate them to audiometric
measures and outcomes; 2) To develop and validate a computational model of the electrode-neuron interface
using histopathology, research and clinical measures; and 3) To improve speech perception for cochlear implant
listeners by individualizing programming based on electrode-neuron interface estimates.
The results of the proposed studies are expected to lead to a shift in how we think about cochlear
histopathology and clinical care of individuals with cochlear implants. We will characterize the largest set of
implanted temporal bones with the highest degree of granularity to date. We will provide insight and tools for
assessing the relationship between histopathology, research, and clinical measures. Finally, we will develop
translatable methods for individualized programming for cochlear implant listeners based on a robust
understanding and a validated model of the electrode-neuron interface in humans.
项目总结/摘要
耳蜗植入物是非常成功的神经假体,可以增强或恢复听力,
听力受损的成人和儿童。来自环境的声音被转换成电脉冲,
通过电极阵列传送到听觉神经。耳蜗植入物提供重要的光谱和
时间听觉信息。然而,语音感知性能差异很大
在耳蜗植入者中,特别是在嘈杂的环境中和对于复杂的刺激。显著
这种性能可变性的一个影响因素是电极-神经元界面的质量,
通过单个电极的位置,神经元、骨骼和组织的相对健康和完整性,
与电极阵列插入造成的创伤相关的生长。
目前,还没有一种临床工具来查询耳蜗植入者中的电极-神经元界面,
也没有基于人类耳蜗组织病理学的精确计算模型来估计电极,
神经元接口提高我们理解的一步是更新经典方法,
定量的密度和完整性的听觉神经元在捐赠的人颞骨从
人工耳蜗植入者我们将利用机器学习的力量来生成3D重建
神经元相对于耳蜗植入阵列中电极的位置。开发临床措施来预测
在电极神经元接口的变化,我们将利用跨学科的专家团队,机器
学习,计算建模,无与伦比的颞骨收集,以及丰富的临床数据。
拟议实验的长期目标是改善人工耳蜗编程和语音
通过提高我们对电极-神经元界面的理解来改善感知结果。
提出了三个目标:1)在耳蜗组织病理学的定量三维地图,
耳蜗植入者颞骨内电极-神经元界面的变化及其与听力的关系
措施和结果; 2)开发和验证电极-神经元界面的计算模型
通过组织病理学、研究和临床措施; 3)改善人工耳蜗植入者的言语感知
通过基于电极-神经元接口估计的个性化编程来帮助听众。
这些研究的结果有望改变我们对耳蜗的看法。
组织病理学和人工耳蜗植入患者的临床护理。我们将描述最大的一组
迄今为止粒度最大的颞骨我们将提供洞察力和工具,
评估组织病理学、研究和临床措施之间的关系。最后,我们将开发
基于鲁棒性的人工耳蜗植入者个性化编程的可翻译方法
了解和验证模型的电极神经元接口在人类。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
JULIE G Arenberg其他文献
JULIE G Arenberg的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('JULIE G Arenberg', 18)}}的其他基金
Development of a Micro-coil Based Cochlear Implant
基于微线圈的人工耳蜗的开发
- 批准号:
10658004 - 财政年份:2023
- 资助金额:
$ 45.35万 - 项目类别:
Perceptual implications of cochlear implant electrode-neuron interfaces
人工耳蜗电极-神经元界面的感知影响
- 批准号:
8415528 - 财政年份:2012
- 资助金额:
$ 45.35万 - 项目类别:
Perceptual implications of cochlear implant electrode-neuron interfaces
人工耳蜗电极-神经元界面的感知影响
- 批准号:
8793692 - 财政年份:2012
- 资助金额:
$ 45.35万 - 项目类别:
Perceptual implications of cochlear implant electrode-neuron interfaces
人工耳蜗电极-神经元界面的感知影响
- 批准号:
8221026 - 财政年份:2012
- 资助金额:
$ 45.35万 - 项目类别:
Perceptual implications of cochlear implant electrode-neuron interfaces
人工耳蜗电极-神经元界面的感知影响
- 批准号:
10604526 - 财政年份:2012
- 资助金额:
$ 45.35万 - 项目类别:
Perceptual implications of cochlear implant electrode-neuron interfaces
人工耳蜗电极-神经元界面的感知影响
- 批准号:
10705794 - 财政年份:2012
- 资助金额:
$ 45.35万 - 项目类别:
Perceptual implications of cochlear implant electrode-neuron interfaces
人工耳蜗电极-神经元界面的感知影响
- 批准号:
8607527 - 财政年份:2012
- 资助金额:
$ 45.35万 - 项目类别:
Probing the cochlea with partial tripolar stimulation in cochlear implantees
通过部分三极刺激探查人工耳蜗植入者的耳蜗
- 批准号:
7457468 - 财政年份:2008
- 资助金额:
$ 45.35万 - 项目类别:
Probing the cochlea with partial tripolar stimulation in cochlear implantees
通过部分三极刺激探查人工耳蜗植入者的耳蜗
- 批准号:
7835618 - 财政年份:2008
- 资助金额:
$ 45.35万 - 项目类别:
相似海外基金
CAREER: Helping or hindering? Determining the influence of repetitive marine heatwaves on acclimatization of reef-building corals across biological scales
事业:帮助还是阻碍?
- 批准号:
2237658 - 财政年份:2023
- 资助金额:
$ 45.35万 - 项目类别:
Continuing Grant
Facility improvements to establish capacity for coral reef resilience research assessing genetic adaptation and physiological acclimatization
改进设施以建立评估遗传适应和生理适应能力的珊瑚礁复原力研究能力
- 批准号:
2147677 - 财政年份:2022
- 资助金额:
$ 45.35万 - 项目类别:
Standard Grant
Neural and muscular aspects of fatigue and long-term acclimatization to high altitude.
疲劳和长期适应高海拔的神经和肌肉方面。
- 批准号:
RGPIN-2020-06977 - 财政年份:2022
- 资助金额:
$ 45.35万 - 项目类别:
Discovery Grants Program - Individual
Neural and muscular aspects of fatigue and long-term acclimatization to high altitude.
疲劳和长期适应高海拔的神经和肌肉方面。
- 批准号:
RGPAS-2020-00038 - 财政年份:2022
- 资助金额:
$ 45.35万 - 项目类别:
Discovery Grants Program - Accelerator Supplements
Adaptation and acclimatization to high altitude in rodents.
啮齿动物对高海拔的适应和适应。
- 批准号:
RGPIN-2019-06495 - 财政年份:2022
- 资助金额:
$ 45.35万 - 项目类别:
Discovery Grants Program - Individual
The role of metabolic-epigenetics in acclimatization to thermal stress in reef-building corals
代谢表观遗传学在造礁珊瑚适应热应激中的作用
- 批准号:
545967-2020 - 财政年份:2022
- 资助金额:
$ 45.35万 - 项目类别:
Postgraduate Scholarships - Doctoral
RII Track-4: Surviving climate change: The role of adaptation and acclimatization in tropical corals
RII Track-4:应对气候变化:适应和适应环境在热带珊瑚中的作用
- 批准号:
2032919 - 财政年份:2021
- 资助金额:
$ 45.35万 - 项目类别:
Standard Grant
The role of metabolic-epigenetics in acclimatization to thermal stress in reef-building corals
代谢表观遗传学在造礁珊瑚适应热应激中的作用
- 批准号:
545967-2020 - 财政年份:2021
- 资助金额:
$ 45.35万 - 项目类别:
Postgraduate Scholarships - Doctoral
Neural and muscular aspects of fatigue and long-term acclimatization to high altitude.
疲劳和长期适应高海拔的神经和肌肉方面。
- 批准号:
RGPIN-2020-06977 - 财政年份:2021
- 资助金额:
$ 45.35万 - 项目类别:
Discovery Grants Program - Individual
Neural and muscular aspects of fatigue and long-term acclimatization to high altitude.
疲劳和长期适应高海拔的神经和肌肉方面。
- 批准号:
RGPAS-2020-00038 - 财政年份:2021
- 资助金额:
$ 45.35万 - 项目类别:
Discovery Grants Program - Accelerator Supplements