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EVALUATION OF ACCURACY OF SPECT IN THE DIAGNOSIS OF BRAIN TUMOR

SPECT诊断脑肿瘤的准确性评价

基本信息

批准号：
08671048
负责人：
MACHIDA Kikuo
金额：
$ 1.34万
依托单位：
SAITAMA MEDICAL SCHOOL
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1996
资助国家：
日本
起止时间：
1996 至 1997
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08671048/
关键词：
IMAGE DATA BASE BRAIN TUMOR T1-201 SPECT MRI ROC curve reading experiment variance among doctors Tl201-SPECT

项目摘要

Fifteen-four studies of ^<20l>T1 brain tumor SPECT were independently interpreted by 9 nuclear medicine physicians with and without reference magnetic resonance images in 2 separate sessions to define an effect of referring images, and inter-observer variations. The physicians were requested to detect foci of abnormal deposits, and to discriminate whether they were malignant or not according to 5-grade scaling of subjective diagnostic confidence. Receiver-operating characteristics (ROC) analysis was performed. Mean sensitivity for presence of lesions (SFP), and sensitivity and specifcity for malignancy of ^<201>T1 SPECT were 84, and 53 and 55%, which were changed to 94, and 74 and 55% after referring to the MR images. The SFP was significantly improved (p<0.05), but sensitivity and specificity for malignancy, assessed by areas under the ROC curves, were not significantly improved. Inter-observer variation of the SFP was significantly reduced with addition of the referring MR images. Cerebral lobar localization of lesions by SPECT showed great inter-observer variations (true localization ranged from 30 to 68.4%). It is concluded that ^<201>T1 brain tumor SPECT has moderate sensitivity and specificity for malignancy, which is not improved by addition of anatomical reference images, that additional MR images reduce inter-observer variation of confidence on lesion presence, and that SPECT localization of lesions has great inter-observer variations.

由<20l>9名核医学医生在2个单独的会议中独立解释154项^ T1脑肿瘤SPECT研究（有或无参考磁共振图像），以确定参考图像的影响和观察者间的差异。要求医生检测异常沉积物的病灶，并根据主观诊断信心的5级评分来区分它们是否是恶性的。进行受试者工作特征（ROC）分析。T1 SPECT对病变存在的平均敏感性（SFP）、对恶性肿瘤的敏感性和特异性<201>分别为84%、53%和55%，参考MR图像后分别为94%、74%和55%。SFP显著改善（p<0.05），但通过ROC曲线下面积评估的恶性肿瘤的敏感性和特异性没有显著改善。SFP的观察者之间的差异显着减少了参考MR图像的添加。SPECT脑叶病变定位显示观察者间差异很大（真实定位范围为30 - 68.4%）。得出结论，^<201>T1脑肿瘤SPECT对恶性肿瘤具有中等灵敏度和特异性，这并没有通过增加解剖参考图像而得到改善，额外的MR图像减少了观察者之间对病变存在的置信度的变化，并且病变的SPECT定位具有很大的观察者之间的变化。