Clinical efficacy of brain blood flow SPECT in the diagnosis of pochiatric disorders in the aged

脑血流SPECT诊断老年痴呆症的临床效果

• 批准号: 10670869
• 负责人: MACHIDA Kikuo
• 金额: $ 2.11万
• 依托单位: Saitama Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10670869/
• 关键词: efficacy; Tc-99m-ECD; Tc-99m-HMPAO; I-123-IMP; alzheimer; Cerebral infarction; Pick; Multi-center study; ニュロライト; セレブロテック; パーヒューザミン; MRI; マグネビスト; dementia; film reading; ニューロライト; パーヒュザミン

Brain perfusion SPECT (BP-SPECT) has characteristic patterns of abnormality enabling differential diagnosis of dementia. The purpose was to measure inter-obserYer variations in diagnosis of dementia using BP-SPECT. BP-SPECT images of 57 cases, 19 of Alzheimer s Disease (AD) eight of multi-infarct dementia (MID), three of Pick's disease, five of other dementias and 22 normal controls, were interpreted by ten nuclear medicine physicians of variable experience before and after the addition of MRl. The physicians independently rated diagnoses that were listed beforehand according to a 5-point scale with clinical information provided. Recejyer-operating characteristics (ROC) curves and the area under the ROC curves (Az) was calculated. Az varied from 0. 48 to O. 87. Mean Az's were significantly larger (p < 0.05) before the addition of MRI than after the addition (0. 715 and 0. 629 for dementia vs, normal, O. 670 and O. 560 for AD or MID vs. normal, O. 610 and O. 416 for AD vs. normal, and O, 669 and O. 443 for AD vs. MID, respectively). Considerable inter-observer variation is present in BP-SPECT interpretation. The addition of MRI lowered the diagnostic usefulness in this study. BP-SPECT may be effective for the evaluation of dementia independent of MRI for nuclear medicine physicians

脑灌注SPECT （BP-SPECT）具有异常的特征性模式，可用于痴呆症的鉴别诊断。目的是测量使用BP-SPECT诊断痴呆的观察者间差异。对57例阿尔茨海默病（AD） 19例、多梗死性痴呆（MID） 8例、匹克病3例、其他痴呆5例及22例正常对照的BP-SPECT图像，由10名不同经验的核医学医师进行加mri前后的解读。医生根据提供的临床信息，按照5分制对事先列出的诊断进行独立评分。计算受试者工作特征（ROC）曲线及ROC曲线下面积（Az）。Az从0变化。48比87。添加MRI前的平均Az值显著大于添加MRI后的平均值（p < 0.05）。715和0。痴呆vs正常人629，AD或MID vs正常人670和560，AD vs正常人610和416，AD vs MID分别为669和443)。在BP-SPECT解释中存在相当大的观察者间差异。MRI的加入降低了本研究的诊断有效性。BP-SPECT可能是核医学医师独立于MRI评估痴呆的有效方法

项目成果

Hosono M, Machida K et al.: "Oligodendroglioma with cystic component in infant"Computerited Medical Imaging and Graphics. 25. 361-365 (2001)

Hosono M、Machida K 等人：“婴儿中伴有囊性成分的少突胶质细胞瘤”计算机医学成像和图形。

本田憲業 他: "Xe-133ガス肺換気シンチグラフィの臨床応用"日本医学放射線学会雑誌. 60・5. 237-242 (2000)

Noriyoshi Honda 等：“Xe-133 气体肺通气闪烁显像术的临床应用”日本医学放射学会杂志 60・5（2000 年）。

Kikuo MACHIDA et al: "Clinical Efficacy of Blood Flow SPECT in the Diagnosis of Alzheimer Disease-ROC Analysis"European Journal of Nuclear Medicine. 26・9. 1126-1126 (1999)

Kikuo MACHIDA 等人：“血流 SPECT 诊断阿尔茨海默病的临床功效 - ROC 分析”欧洲核医学杂志 26・9（1999）。

Hosono M et al.: "Two-step targeting and dosimetry for small cell lung cancer xenograft with anti-NCAM/antihistamine…"J Nucl Med. 40. 1216-1221 (1999)

Hosono M 等人：“使用抗 NCAM/抗组胺药物进行小细胞肺癌异种移植物的两步靶向和剂量测定……”J Nucl Med，40. 1216-1221 (1999)

町田喜久雄他: "脳MRIの意義と正常解剖"Medical Practice. 16. 869-877 (1999)

Kikuo Machida 等人：“脑 MRI 和正常解剖学的意义”医学实践 16. 869-877 (1999)。