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Effects of coordinated stimulations triggered by interictal discharges on kindling-induced epileptogenesis.

发作间期放电触发的协调刺激对点燃诱发的癫痫发生的影响。

基本信息

批准号：
08671114
负责人：
KOGURE Shinichi
金额：
$ 1.22万
依托单位：
SOKA UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1996
资助国家：
日本
起止时间：
1996 至 1997
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08671114/
关键词：
hippocampus kindling interictal discharge epileptogenesis afterdischarge threshold afterdischarge threshold

项目摘要

It is generally accepted that kindling-induced interictal discharges (IIDs) are almost similar to IIDs of epileptic patients. However, their general characteristics, i.e., whether they reflect an excitatory event or an inhibitory one and how they are generated, are still unknown. In previous studies, we classified kindling-induced IIDs into three types : simple A,simple B and complex. The complex type consisted of two-three simple IIDs, and its frequency was associated with the development of behavioral responses during kindling.The present experiment was designed to reveal effects of coordinated stimulations triggered by IIDs on epileptogenes induced by hippocampal kindling of the rabbits. Out of 17 animals, ten developed stage 5 convulsions with a mean of 19 stimulations (K group), whereas the remaining did not (IK group). Before daily kindling stimulation, a coordinated stimulation, which was a miniature type of kindling stimulation either driven at random (RS) or triggered by the I … More ID (TS), was applied to generate an afterdischarge while changing stimulus parameters. The final stimulus intensity (voltage*frequency*no.of train) was standardized based on those of kindling and referred to as a standard intensity index (SII). In K group, averaged SIIs were 28(]SY.+-。[)3% (when the stimuli were triggered by simple A type of IIDs : n=7), 32(]SY.+-。[)4% (simple B : n=16) and 39(]SY.+-。[)4% (complex : n=24), while it was 38(]SY.+-。[)5% when applied at random (n=79). Those of IK group were 48(]SY.+-。[)5% (simple A : n=11), 75(]SY.+-。[)4% (simple B : n=4), 42(]SY.+-。[)3% (complex : n=10) and 55(]SY.+-。[)5% (at random : n=52), respectively. The SII differences between TS and RS were -10 to -7% (simple A), -6 to +20% (simple B) and -23 to +1% (complex). Since negative values indicate weaker stimuli to generate afterdischarges than RS intensity whereas positive values do stronger ones, it is concluded that simple B type of IIDs has suppressive effect on seizure susceptibility while simple A and complex IIDs have facilitatory effect. Less

人们普遍认为，点燃诱发的发作间期放电(IID)与癫痫患者的IID几乎相似。然而，它们的一般特征，即它们是反映兴奋性事件还是抑制性事件，以及它们是如何产生的，仍然是未知的。在以前的研究中，我们将点燃诱导的IID分为三种类型：简单的A、简单的B和复杂的。复合型IIDs由2-3个简单IIDs组成，其频率与点燃过程中行为反应的发展有关。本实验旨在揭示IIDs触发的协同刺激对兔海马区点燃所致癫痫的影响。在17只动物中，10只发生了5级惊厥，平均19次刺激(K组)，其余的没有(IK组)。在日常点燃刺激之前，一种协调刺激，它是随机(RS)或由I…触发的一种微型点燃刺激在改变刺激参数的同时，应用更多的ID(TS)，以产生后放电。最后的刺激强度(电压*频率*列车编号)根据点燃的强度进行标准化，并称为标准强度指数(SII)。K组平均SIIS为28(SY+-)。[)3%(当刺激由简单的A型IID触发时：n=7)，32()sy+-。[)4%(简单B：n=16)和39()SY+-。[]4%(络合物：n=24)，38(]sy.+-。[]随机应用5%(n=79)。IK组48例(SY+-)。[)5%(简单A：n=11)，75%([SY+-])。[)4%(单纯B：n=4)，42()SY+-。[)3%(络合物：n=10)和55()sy.+-。[]5%(随机：n=52)。TS和RS的SII差值分别为-10%~-7%(简单A)、-6%~+20%(简单B)和-23%~+1%(复杂)。负值表示产生后放电的刺激强度弱于RS强度，而正值表示产生后放电的刺激强度较强，因此认为单纯B型IIDs对惊厥敏感性有抑制作用，而简单A型IIDs和复合IIDs具有易化作用。较少