A basic study to develop the low-power laser therapy for Intractable epilepsies

得到以下结果：i)测量低功率激光照射（LLI: 532nm, 50mW/80mW, 10min）前后的阵发性放电阈值（PADT）。LLIs使平均PADT增加至1.38(p<0.05)/1.94（p<0.01）倍。ii)利用膜片钳技术，研究了LLI对离子通道的影响。LLI不仅影响动作电位，降低动作电位的阈值，而且还延长重复放电的峰间间隔。这表明LLI有可能通过激活K+通道来抑制突发放电的产生。

The following results were obtained : i) The paroxysmal discharge threshold(PADT) was measured before and after low-power laser irradiation(LLI : 532nm, 50mW/80mW, 10min). LLIs increased the average PADT to 1.38(p<0.05)/1.94(p<0.01) times. ii) Using patch clamp technique, the effects of LLI on ion channels were examined. LLI affected not only the action potential with decreasing its threshold, but also the prolongation of inter-spike interval of repetitive firing. It is suggested that LLI has a potential to suppress the generation of burstic discharge via activating K+channels.