Analysis of breast cancer extension using new imaging technology, 3-D MRI

使用新成像技术 3-D MRI 分析乳腺癌扩散

• 批准号: 08671328
• 负责人: OHUCHI Noriaki
• 金额: $ 1.34万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08671328/
• 关键词: breast cancer; breast conserving surgery; intraductal spread of carcinoma; magnetic resonance imaging; 3-D mapping; 乳房温存療法:breast conserving therapy; 3次元MRI:3-D MRI; 乳管内進展:intraductal spreading

[Introduction]Now, definition of carcinoma extension becomes more important, as breast conserving therapy is accepted as one of the treatment options. This study was initiated to clarify the ability of magnetic resonance imaging (MRI) in defining the extension of breast carcinoma, in comparison with the pathologic finding created by subserial sectioning of the specimens.[Materials and Methods]Prior to surgery the MRI was performed to 34 patients with breast cancer, then extension of tumors were 3 dimensionally assessed in maximum intensity projection (MIP). Each 3-D MIP was compared to the respective pathologic distribution of carcinoma obtained by subserial mapping.[Results and Discussion]Three imaging patterns were obtained, e.g., 1) localized (n=20), 2) segmental (n=11), and 3) random extensive (n=3) types. Among the specimens classified in localized type, 18 were defined in the TDLU,and intraductal spread of carcinoma to the nipple as long as 4 cm of extension, was observed in 2 specimens. In most of the specimens with segmental type carcinomas distributed along the duct-lobular system from the TDLU to the large duct. Clearly stained tumors in the MRI were histologically revealed to be DCIS which forms solid mass. Three were categorized as random extensive type with linear architecture, and were histologically defined to be carcinomas with diffuse stromal invasion as intraductal spread.Conventional mammography and ultrasonography underestimated carcinoma extension in 6 of the 14 patients who were categorized as segmental, or random extensive type by the MRI,suggesting that the MRI is more appropriate to estimate carcinoma distribution prior to surgery. Ten percent (2/20) of patients with localized type, however, were not visualized in the MRI.Further investigation is required to develop the diagnostic technology in clinical utilization of MRI for breast conserving surgery.

[导言]现在，随着保乳治疗被接受为治疗方案之一，对肿瘤扩展的定义变得更加重要。[材料与方法]对34例乳腺癌患者术前行MRI检查，然后用最大密度投影法(MIP)对肿瘤范围进行三维评估。[结果与讨论]获得了3种不同的成像模式：1)定位型(n=20)，2)节段型(n=11)，3)随机扩散型(n=3)。在局限型标本中，18例在TDLU中明确，2例发现癌在导管内扩散至乳头，最长达4 cm。节段型癌多沿TDLU至大管的导管-小叶系统分布。MRI中染色清晰的肿瘤在组织学上显示为DCIS，形成实性肿块。常规钼靶摄影和超声检查低估了14例MRI诊断为节段型或随机广泛型患者中的6例，提示MRI更适合于术前评估肿瘤的分布。然而，10%(2/20)的局限型患者在MRI中没有被显示，这需要进一步的研究来发展临床应用MRI在保乳手术中的诊断技术。

项目成果

Ikegaki H,Ohuchi N,Masuko T,Suzuki S,Mori S,Hashimoto Y.: "Characterization and in vitro cytotoxic effect of Adriamycin-conjugated monoclonal antibodies prepared against breast cancer cell line." Breast Cancer. 4. 85-92 (1997)

Ikegaki H、Ohuchi N、Masuko T、Suzuki S、Mori S、Hashimoto Y.：“针对乳腺癌细胞系制备的阿霉素偶联单克隆抗体的表征和体外细胞毒性作用。”

Taeda Y,Nose M,Hiraizumi S,Ohuchi N.: "Expression of LPHA-binding protein in breast cancer : reconstitution and molecular characterization of beta1-6 branched oligosaccharides in three-dimensional cell culture." Breast Cancer Res Trest. 38. 313-324 (1996)

Taeda Y、Nose M、Hiraizumi S、Ohuchi N.：“乳腺癌中 LPHA 结合蛋白的表达：三维细胞培养物中 β1-6 支链寡糖的重建和分子表征。”

Ikeda T, Ohuchi N, et al.: "The current status of the treatment of ductal carcinoma in situ of Japanese women,especially breast conserving operation in relation to the surgical margin and short term outcome." Breast Cancer. 5. 53-58 (1998)

Ikeda T, Ohuchi N, et al.：“日本女性导管原位癌的治疗现状，特别是保乳手术与手术切缘和短期结果的关系。”

天野吾郎、大内憲明、他。: "3次元MRIによる乳癌進展の解析:多数切片作製による病理組織像との対応" 乳癌の臨床. 12. 640-641 (1997)

天野五郎、大内典明等。

天野吾郎、大内憲明、他。: "新しい画像処理による乳癌進展の解析と乳房温存療法への応用." Innervision. 12. 76- (1997)

天野五郎、大内典明等。