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Magnetic resonance imaging of breast cancer : Correlation between contrast enhancement and tumor angiogenesis

乳腺癌的磁共振成像：对比增强与肿瘤血管生成之间的相关性

基本信息

批准号：
10671092
负责人：
OHUCHI Noriaki
金额：
$ 1.47万
依托单位：
TOHOKU UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 1999
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10671092/
关键词：
Breast cancer Breast conserving 3-D MR imaging Angiogenesis Histological grade 乳癌温存療法 3次元MRI画像

项目摘要

[Purpose] To evaluate the association between enhancement characteristics of breast cancers obtained by three-dimensional dynamic MRI and histopathologic findings, especially tumor angiogenesis.[Materials and Methods] Forty-four women with invasive breast cancer underwent preoperative MR imaging. Three-dimensional fast flow angle shot (3D-FLASH) images of the whole breast (section thickness, 2 mm ; gap, 0 mm ; number of sections, 50 ; acquisition time, 87 sec) were obtained at 90-second intervals for three times (the first images before injection of Gd-DTPA). Microvessel densities were evaluated in specimens immunohisto-chemically stained with anti-CD34 antibody. The person correlation tests were used to determine the strength of the relationships between enhancement parameters and microvessel densities. Univariate and multivariate analyses were performed to explore these association with histopathologic factors including histological grade.[Results] The enhancement parameters were correlated with microvessel densities (p<0.0001). The peripheral microvessel densities were significantly higher than the central microvessel densities (p<0.0001). A significant association to histological grade was observed in steepest slopes of dynamic curve and microvessel densities (p<0.05).[Conclusion] A correlation between 3-D dynamic MRI parameters and microvessel densities, and those association to histological grade were observed. This may allow MRI to be utilized for predictions of tumor angiogenesis and histological grade.

[目的]探讨乳腺癌三维动态增强特征与组织病理学尤其是肿瘤血管生成的关系。[材料与方法]44例乳腺浸润性癌术前行MR检查。在注射Gd-DTPA前的第一张图像上，以90秒的间隔获得全乳房的三维快速流动角扫描(3D-Flash)图像(层厚2 mm；间隙0 mm；层数50层；采集时间87秒)。用抗CD34抗体对标本进行免疫组织化学染色，检测微血管密度。使用人员相关性检验来确定增强参数与微血管密度之间关系的强度。[结果]增强参数与微血管密度呈正相关(p&lt；0.0001)。外周微血管密度显著高于中心微血管密度(p&lt；0.0001)。动态曲线的最陡斜率和微血管密度与组织学分级显著相关(p&lt；0.05)。[结论]三维动态MRI参数与微血管密度及其与组织学分级相关。这可能使MRI被用于预测肿瘤血管生成和组织学分级。