Development of nano-particles with tumor retention by single molecular DDS imaging

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To develop an effective anticancer drug, the understanding of cancer mechanisms and drug delivery system (DDS) is very important. Here, we have developed a method for in vivo imaging with very high spatial accuracy and succeeded in tracking the membrane protein PAR1 during metastasis in living mice. To investigate drug movement in association to its size in tumor, fluorescent nano-particles were injected into the tumor-bearing mice and visualized by in vivo imaging. Additionally, we developed a novel method to evaluate the structural stability and anti-cancer effect of drug-incorporating polymeric micelles.