Continuous hemofiltration of low molecular protein (CHF-LP) in patients at high risk of liver failure after hepatectomy

肝切除术后肝功能衰竭高危患者的低分子蛋白连续血液滤过（CHF-LP）

• 批准号: 08671447
• 负责人: NISHIDA Minekatsu
• 金额: $ 1.41万
• 依托单位: Yamaguchi Univeristy
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08671447/
• 关键词: Liver failure; hepatectomy; plasmapheresis; LCAT; Hyaluronic acid; Cytokine; IL-6; Endotoxin; 肝切除術; IL-Ira; IL-8; Alka phospase ratio

The correct management of postoperative hepatic failure following heaptectomy depends on an understanding of the mechanisms behind these abnormalities both to prevent the development of multiorgan failure and to optimally manage patients in whom some organ damage has already developed. However, the onset of the postoperative hepatic failure following hepatectomy usually proceed to multiorgan failure, maybe due to liver to other organ interaction. Thus, patients in whom excessive hepatectomy were carried out, were treated by a hemofiltration using the EVAL secondary membrane filers to remove inflammatory mediators on first postoperative day. Dramatic improvements were seen in hepatic parameters, and the effects were lasting for several days, even though the hemofiltration had been carried out only one day. These resulsts suggested that the hemofiltration using the EVAL secondary membrane filers removed inflammatory mediators on first postoperative day after hepatectomy.

肝切除术后肝功能衰竭的正确处理依赖于对这些异常背后的机制的了解，以防止多器官衰竭的发展和对已经出现一些器官损伤的患者进行最佳处理。然而，肝切除术后发生的肝功能衰竭通常会进展为多器官衰竭，可能是由于肝与其他器官的相互作用所致。因此，过度肝切除的患者在术后第一天使用EVAL二次滤膜器进行血液滤过以去除炎症介质。尽管血液滤过只进行了一天，但肝脏参数出现了戏剧性的改善，而且效果持续了几天。这些结果表明，使用EVAL二次滤膜的血液滤过在肝切除术后第一天就去除了炎性介质。

项目成果

Takashi Takao: "Continuous hemofiltration of low molecular protein (CHF-LP) in patients at high risk of liver failure after hepatectomy" J.of Hepato-Biliary-Pancreatic Surgery. 3 (3). 99 (1996)

Takashi Takao：“对肝切除术后肝功能衰竭高风险患者进行低分子蛋白连续血液滤过（CHF-LP）”J.of Hepato-Biliary-Pancreatic外科杂志。

Yoshitaka Maeda: "Usefulness of preventive hemofiltration for liver failure after hepatectomy in whom Alkaline phosphatase ratio was lower than 0.4" The Japanese Journal of Gastroenterological Surgery. 30 (6). 153 (1997)

Yoshitaka Maeda：“预防性血液滤过对于碱性磷酸酶比率低于 0.4 的肝切除术后肝功能衰竭的有用性”《日本胃肠外科杂志》。

西田 峰勝: "肝切除術後多臓器不全に対する予防対策-術直後低分子領域蛋白除去療法について-" 日本臨床外科医学会雑誌. 57(増刊号). 129 (1996)

Minekatsu Nishida：“肝切除术后多器官衰竭的预防措施 - 术后立即去除低分子量蛋白治疗”，日本临床外科医师学会杂志 57（特刊）。

Minekatsu Nishida: "A new trial to prevent postoperative liver failure after hepatectomy" Acta Hepatologica Japonica. 37 (1). 179 (1996)

Minekatsu Nishida：“一项预防肝切除术后肝功能衰竭的新试验”Acta Hepatologica Japonica。

高尾 貴史: "肝切除術後肝不全high riskグループに対する術直後低分子蛋白除去療法" 第8回日本肝胆膵外科学会プログラム. 99 (1996)

Takashi Takao：“肝切除术后肝衰竭高危人群的术后立即低分子量蛋白去除治疗”第8届日本肝胆胰外科学会计划99（1996）。