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MECHANISTIC ANALYSIS AND ENHANCEMENT OF CELL DEATH OF HUMAN PANCREATIC CANCER CELL LINE EXPOSED BY HIGH DOSE X-RAY IRRADIATION - FOR THE IMPROVEMENT OF ADJUVANT CHEMOTHERPY OF PANCREATIC CANCER

MECHANISTIC ANALYSIS AND ENHANCEMENT OF CELL DEATH OF HUMAN PANCREATIC CANCER CELL LINE EXPOSED BY HIGH DOSE X-RAY IRRADIATION - FOR THE IMPROVEMENT OF ADJUVANT CHEMOTHERPY OF PANCREATIC CANCER
高剂量 X 射线照射下人胰腺癌细胞系细胞死亡的机制分析和增强 - 用于改善胰腺癌的辅助化疗
批准号:
08671457
负责人:
MIZUMOTO Kazuhiro
金额:
$0.45万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
1996
资助国家:
日本
项目状态:
已结题
起止时间:
1996 至 1997

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中文摘要
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英文摘要
Effect of etoposide on the cell deaths of a human pancreatic cancer cell line by exposure to high dose X-ray irradiation was examined. Both high dose X-ray irradiation and etoposide killed the pancreatic cancer cells by apoptosis. With 30 gray irradiation, simultaneous treatment of etoposide did not alter the percentage of cell deaths ; however, 24-hr prior treatment of etoposide killed a significantly larger percentage of the cells, accompanying the accumulation to the S phase of the cell cycle. The results indicates that apoptosis of human pancreatic cancer cell line induced by high dose X-ray irradiation can be enhanced by the prior treatment of etoposide.
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通讯作者:
水元一博 他: "膵癌に対する大量X線照射とEtoposideの併用効果" 癌と化学療法. 23(12). 1673-5 (1996)
Kazuhiro Mizumoto 等人:“高剂量 X 射线照射和依托泊苷联合治疗胰腺癌的效果”,癌症与化疗,1673-5 (1996)。
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郭錦秋、水元一博 他: "大量X線照射によるヒト膵・胆嚢癌培養細胞株のアポトーシス" 膵臓. (印刷中).
金秋郭,Kazuhiro Mizumoto 等:“高剂量 X 射线照射诱导的人胰腺和胆囊癌细胞系的凋亡”胰腺(出版中)。
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7
    Construction of drug discovery library using PDX-3D method and discovery of novel therapeutic agents for pancreatic cancer
    Induction of tumor-suppressing pancreatic stellate cell subpopulation by pancreatic cancer microenvironment reprogramming
    • 批准号:
      15H04933
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $10.65万
    • 财政年份:
      2015
    • 负责人:
      MIZUMOTO Kazuhiro
    • 依托单位:
    Biological and clinical significance of niche during carcinogenesis in pancreatic cancer
    • 批准号:
      25670585
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.41万
    • 财政年份:
      2013
    • 负责人:
      MIZUMOTO Kazuhiro
    • 依托单位:
    Identification of the key stromal cell responsible for desmoplasia of pancreatic cancer, elucidation of the origin of it, and regulation of its function
    • 批准号:
      24390319
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.65万
    • 财政年份:
      2012
    • 负责人:
      MIZUMOTO Kazuhiro
    • 依托单位:
    海外基金