Molecular Evaluation of Effectsof Inhalational Anesthetics on Post-Operative Recovery after Liver Surgery.

吸入麻醉药对肝脏手术后术后恢复影响的分子评价。

• 批准号: 08671728
• 负责人: KIMURA Nobuyuki
• 金额: $ 1.34万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08671728/
• 关键词: Liver Surgery; Heart Rate Variability; Volatile Anesthetics; Intravenous Anesthetics; Nonlinear Analysis

We Investigated the effects of inhalational general anesthetics on the amount of mRNA in liver cells after hepatectomy in rats. But no suppressive effect was observed. Then we changed the subject and the method. Hemodynamic stability may be very important factor for post-operative recovery of liver surgery. We investigated the effect of volatile and intravenous anesthetics on the dynamics of heart rate variability (HRV) in humans.Isoflurane, popular volatile anesthetics, decreased not only each frequency components with frequency domain analysis of HIRV but Lyapunov exponent and correlation dimension of HRV time series data. In the other hand, propofol-fentanyl anesthesia did not decreased approximate entropy of HRV.Surgical noxious stimuli remarkably decreased nonlinear parameters of HRV.

我们研究了吸入性全身麻醉药对大鼠肝切除术后肝细胞mRNA含量的影响。但未观察到抑制作用。然后我们改变了主题和方法。血流动力学的稳定性可能是肝脏手术后恢复的重要因素。本文研究了吸入麻醉药和静脉麻醉药对心率变异性（HRV）的影响，采用频域分析的方法研究了常用的吸入麻醉药异氟醚对心率变异性（HIRV）的影响，发现异氟醚不仅降低了心率变异性（HRV）的各频率成分，而且降低了HRV时间序列数据的李雅普诺夫指数和关联维数。异丙酚-芬太尼麻醉不降低HRV的近似熵，手术伤害性刺激显著降低HRV的非线性参数。

项目成果

KIMURA T: "Use of Spectral Edge Frequency of Heart Rate Variability as an Index of Cardiac Autonomic Balance" Anesth Analg. 84. S247 (1997)

KIMURA T：“使用心率变异性的频谱边缘频率作为心脏自主平衡的指标”麻醉模拟。

KOMATSU T: "Effects of Midazolam and Ketamine on Heart Rate Variability as an Indicator of Dynamics of Cardiovascular System" NEW BALANCED ANESTHESIA. 65-67 (1998)

KOMATSU T：“咪达唑仑和氯胺酮对作为心血管系统动态指标的心率变异性的影响”新平衡麻醉。

T Komatsu: "Effects of Midazolam and Ketamine on Heart Rate Variability as an indicator of Dynamics of Cardiovascular System" NEW BALANCED ANESTHESIA. 65-67 (1998)

T Komatsu：“咪达唑仑和氯胺酮对作为心血管系统动态指标的心率变异性的影响”新平衡麻醉。