Interaction between physiological activity and molecular form of natriuretic peptide

利尿钠肽的生理活性与分子形式之间的相互作用

• 批准号: 08671768
• 负责人: GOTO Fumio
• 金额: $ 1.22万
• 依托单位: Gunma University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08671768/
• 关键词: natriuretic peptide; renal function; cardiac function; eel; ウナギ利尿ペプチド; ヒト利尿ペプチド

A new type of natriuretic peptide with an extended C-terminal tail, ventricular natriuretic peptide (VNP), has been isolated from eel cardiac ventricles. We investigated the effect of eel VNP on the kidney and cardiovascular system, and compared these activity with those of mammalian peptides, hANP hBNP,in dogs. All peptides produced similar diuresis and natriuresis, but cardiac output and the left and right ventricular stroke works were decreased by hBNP,but hANP and eel VNP did not change these parameters. Systemic vascular resistance was increased by hBNP,but unaffected by other peptides.These results show that eel VNP has renal effects similar to ANP and BNP,but itelicits responses in the heart different from those of human natriuretic peptides in anesthetized dogs. We are now advancing peptide research to opioid system and pain control system in the central nervous sytem.

从鳗鱼的心脏中分离到一种新型的具有延长C末端尾巴的利钠肽，即室利钠肽(VNP)。我们研究了鳗鱼VNP对狗肾脏和心血管系统的影响，并与哺乳动物多肽hANP hBNP的活性进行了比较。HBNP可减少心输出量和左、右室每搏做功，但hANP和鳗鱼VNP不改变这些参数。这些结果表明，鳗鱼VNP具有与ANP和BNP相似的肾脏效应，但在心脏引起的反应与人钠尿肽不同。我们现在正在推进中枢神经系统中阿片系统和痛觉控制系统的多肽研究。

项目成果

西川 光一, 後藤 文夫 他: "ハロセン抵抗性を示すショウジョウバエ変異株における神経筋シナプス伝達の解析" Journal of Anesthesia. (Abstract). 447- (1997)

Koichi Nishikawa、Fumio Goto 等人：“表现出氟烷抗性的果蝇突变体的神经肌肉突触传递分析”麻醉杂志（摘要）447-（1997 年）。

Fumio Goto,et al.: "Effect of eel ventricular natriuretic peptide on the kidney and cardiovascular system in the dog." Endocrine Journal. 43・2. 205-210 (1996)

Fumio Goto 等人：“鳗鱼心钠素对狗肾脏和心血管系统的影响”，内分泌杂志 43・2（1996 年）。

Masayasu ARAI,Fumio GOTO,YoshioTAKEI: "Effect of Eel Ventricular Natriuretic Peptide on the Kidney and cardiovascular system in the Dog." Endc.J.43(2). 205-210 (1996)

Masayasu ARAI、Fumio GOTO、Yoshio TAKEI：“鳗鱼心室钠尿肽对狗肾脏和心血管系统的影响”。

Makoto Sudo, Keisuke Tsuzuki, Fumio Goto, Seiji Ozawa: "Functional expression of AMPA-type glutamate receptor channcls in PC12 cells using adenoviral vectors." 44^<th> Annual Congress of japan Societyof Anesthesiology, April 23-25,1997. Niigata J Anesthes

Makoto Sudo、Keisuke Tsuzuki、Fumio Goto、Seiji Ozawa：“使用腺病毒载体在 PC12 细胞中功能表达 AMPA 型谷氨酸受体通道。”

Fumio, Goto, et al: "Hypertonic saline for intraoperative fluid therapy in transurethral resection of theprostate" Journal of Anesthesia. 10. 170-175 (1996)

Fumio, Goto 等人：“经尿道前列腺切除术术中液体治疗的高渗盐水”麻醉杂志。