Interaction between physiological activity and molecular form of natriuretic peptide

从鳗鱼心室中分离到一种新型的长c端尾钠肽——心室钠肽（VNP）。我们研究了鳗鱼VNP对肾脏和心血管系统的影响，并将这些活性与哺乳动物肽（hANP hBNP）在狗体内的活性进行了比较。所有多肽均产生相似的利尿和利钠作用，但hBNP可降低心输出量和左、右心室搏功，而hANP和eel VNP未改变这些参数。hBNP增加全身血管阻力，但不受其他肽的影响。这些结果表明，鳗鱼VNP具有与ANP和BNP相似的肾脏作用，但在麻醉犬的心脏中引起的反应与人利钠肽不同。目前，我们正在推进中枢神经系统中阿片系统和疼痛控制系统的肽研究。

A new type of natriuretic peptide with an extended C-terminal tail, ventricular natriuretic peptide (VNP), has been isolated from eel cardiac ventricles. We investigated the effect of eel VNP on the kidney and cardiovascular system, and compared these activity with those of mammalian peptides, hANP hBNP,in dogs. All peptides produced similar diuresis and natriuresis, but cardiac output and the left and right ventricular stroke works were decreased by hBNP,but hANP and eel VNP did not change these parameters. Systemic vascular resistance was increased by hBNP,but unaffected by other peptides.These results show that eel VNP has renal effects similar to ANP and BNP,but itelicits responses in the heart different from those of human natriuretic peptides in anesthetized dogs. We are now advancing peptide research to opioid system and pain control system in the central nervous sytem.