Interaction between physiological activity and molecular form of natriuretic peptide

从鳗鱼心室中分离到一种C末端延长的新型利钠肽--心室利钠肽（ventricular natriuretic peptide，VNP）。我们研究了鳗鱼VNP对肾脏和心血管系统的影响，并将这些活性与哺乳动物肽hANP hBNP在狗中的活性进行了比较。所有肽产生相似的利尿和利钠，但心输出量和左，右心室每搏功减少hBNP，但hANP和鳗鱼VNP没有改变这些参数。结果表明，在麻醉犬中，鳗鱼VNP具有与ANP和BNP相似的肾脏效应，但在心脏中的反应与人钠尿肽不同。目前，我们正在将肽类研究推进到中枢阿片系统和疼痛控制系统。

A new type of natriuretic peptide with an extended C-terminal tail, ventricular natriuretic peptide (VNP), has been isolated from eel cardiac ventricles. We investigated the effect of eel VNP on the kidney and cardiovascular system, and compared these activity with those of mammalian peptides, hANP hBNP,in dogs. All peptides produced similar diuresis and natriuresis, but cardiac output and the left and right ventricular stroke works were decreased by hBNP,but hANP and eel VNP did not change these parameters. Systemic vascular resistance was increased by hBNP,but unaffected by other peptides.These results show that eel VNP has renal effects similar to ANP and BNP,but itelicits responses in the heart different from those of human natriuretic peptides in anesthetized dogs. We are now advancing peptide research to opioid system and pain control system in the central nervous sytem.