Mechanism of natriuretic diuresis induced by natriuretic peptide

利钠肽诱导利尿钠利尿的机制

• 批准号: 06671551
• 负责人: GOTO Fumio
• 金额: $ 1.28万
• 依托单位: Kitasato University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06671551/
• 关键词: Ventricular natriuretic peptide; Eel; BNP; Renal function; Cardiac function; ANP; Dog; 心機能

Ventricular natriuretic peptide (VNP), a possibly new type of natriuretic peptide with an extended C-terminal tail, has been isolated from eel cardiac ventricles. We investigated the effects of eel VNP on the kidney and cardiovascular system and compared these results with those of mammalian peptides in dogs. Eel VNP,human (dog) ANP,human and dog BNP were infused into the renal artery at non-hypotensive doses. All peptides produced similar diuresis and natriuresis. However, cardiac output and left and right ventricular stroke work were decreased by BNPs, but ANP and eel VNP did not change these parameters. Systemic vascular resistance was increased by BNPs, but unaffected by other peptides.These results show that eel VNP has renal effects similar to ANP and BNP,whereas it elicits responses in the heart different from those of BNPs in anesthetized dog. This study suggests that eel VNP is a new ventricular natriuretic peptide and a different peptide from BNPs.

室性利钠肽(VNP)是从鳗鱼的心脏中分离得到的一种可能具有延长C末端尾巴的新型利钠肽。我们研究了鳗鱼VNP对狗肾脏和心血管系统的影响，并将这些结果与哺乳动物多肽的结果进行了比较。将鳗鱼VNP、人(犬)ANP、人和犬BNP以非降压剂量注入肾动脉。所有的多肽都有相似的利尿和利钠作用。然而，BNPS可减少心输出量和左、右室每搏做功，但ANP和鳗鱼VNP不改变这些参数。BNPS可增加全身血管阻力，但不受其他多肽的影响，提示鳗鱼VNP具有与ANP和BNP相似的肾脏效应，但引起的心脏反应与BNPS不同。提示鳗鱼VNP是一种新的脑利钠多肽，与BNPS不同。

项目成果

Arai Masayasu: "Effect of eel ventricular natriuretic peptide on the〜" Endocrine Journal. 43. (1996)

新井雅康：“鳗鱼心室钠尿肽的作用～”内分泌杂志43。（1996）

Goto Fumio: "Renal and cardiac effects of eel ventricular natriuretic peptide" 11th World Congress of Anesthesiologists. (1996)

后藤文雄：“鳗鱼心室钠尿肽对肾脏和心脏的影响”第 11 届世界麻醉医师大会。

Goto Fimio: "Renel and cardiac effects of eel ventricular〜" 11th World Congress of Anesthesiologists. (1996)

后藤菲米奥：“鳗鱼心室的雷内尔和心脏作用〜”第11届世界麻醉医师大会（1996年）。

Arais Masayasu,Goto Fumio: "Effect of eel ventricular natriuretic peptide on the kidney and cardiovascular system" Endocrine Journal. 43. (1996)

Arais Masayasu，Goto Fumio：“鳗鱼心室钠尿肽对肾脏和心血管系统的影响”内分泌杂志。

新井正康,後藤文夫: "高張食塩液の心機能に対する作用機構の解折" Journal of Anesthesia. 9. 307- (1995)

Masayasu Arai、Fumio Goto：“阐明高渗盐水对心脏功能的作用机制”《麻醉杂志》9. 307- (1995)。