2022 Control of Renal Function in Health & Disease: New Frontiers

肾脏功能在健康和疾病中的控制：新领域

2022 Control of Renal Function in Health and Disease: New Frontiers Project Summary/Abstract This NIH R13 grant application seek support for a travel award program for the upcoming 2022 conference entitled “Control of Renal Function in Health and Disease: New Frontiers”. The American Physiological Society and the American Society of Nephrology are sponsoring the conference which is scheduled for June 26-30, 2022 in Charlottesville, Virginia. There are several major translational and therapeutic areas included in the meeting that have relevance to the scientific community. Nearly 30% of the U.S. population has hypertension and only 50% of individuals with hypertension have their blood pressure controlled. Human and animal studies have shown that hypertension changes the kidney’s ability to regulate salt and water homeostasis, both affected by renal hemodynamic and inflammation-mediated mechanisms. Thus, the kidney plays a key role in the pathogenesis of hypertension and is a major target of end-organ-damage that further exacerbates hypertension. In addition, the growing epidemic of obesity, metabolic syndrome and diabetes has led to a large increase in the incidence of chronic kidney disease (CKD). Finally, acute kidney injury (AKI) is also on the rise as a result of increasing ischemic and nephrotoxic events. We must gain a better understanding as to how renal injury occurs as a result of hypertension, CKD, and AKI. In the last 5 years, there have been several novel methodologies developed to study kidney function and disease that would be of interest to renal physiologists and nephrologists alike. Thus, there is a great need in the scientific community for a conference focused on these topics. The organizing committee has developed a meeting program that focuses on novel areas of kidney function and disease including symposia on the following topics: obesity, diabetes and metabolic syndrome; inflammation and the kidney; developmental programming of kidney disease; genetics, epigenetics of the kidney; immunology and the kidney, circadian biology of kidney function, single cell RNASEQ in kidney disease and organoids. Symposia will also cover recent advances in traditional areas of renal hemodynamics, acute kidney injury, integrative control of kidney function, chronic kidney disease, autacoids and nutrition in kidney function and hypertension. In order to promote the interest of trainees and early career investigators in the field and their participation in the conference, we propose to administer an NIH-funded travel award program for trainees and early career investigators.