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Development of a new hemopurification therapy using recycle filtration system.

使用循环过滤系统开发新的血液净化疗法。

基本信息

批准号：
08671845
负责人：
KITAMURA Makoto
金额：
$ 1.6万
依托单位：
Tokai University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1996
资助国家：
日本
起止时间：
1996 至 1998
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08671845/
关键词：
renal failure hemofiltration recycle filtration blood purification recycle filtration fluid purification conventional membranes endotoxin contamination tap water

项目摘要

A new recycle filtration (RF) system for blood purification was developed. This new system is as safe as a conventional dialysis against endotoxin back contamination form the dialysate ; does not require substitution fluid ; and can be applied to hemofiltration, continuous bemofiltration, hemodiafiltration and continuous hemodiafiltration therapies. An in vitro experiment using drain fiuid from hemofiltration showed that an increased recycle fluid flow is accompanied by increased urea nitrogen (UN) and creatinine (Cr) clearances in the dialysis unit and increased beta- 2- microglobulin (beta- MG) clearance in the filtration unit, and a lowered recycle rate. No significant decrease in beta- MG clearance with time in the dialysis unit was observed during 24 hours of continuous recycle. In an in vitro experiment using bovine blood and a polysulfone membrane in the first filter, endotoxin was not detected in the recycled fluid even with a dialysate reconstituted by tap water. At a blood flow of 210 ml/min and recycle fluid flow of 80 mVmin, the respective clearauce of UN,Cr and beta 2- MG was 80.9 * 1.0, 72.0 * 2.5 and 40.1* 0.9 mVmin. These results suggest that the RF system may be used in maintenance dialysis .Clinical efficiency of RFS were studied. Efficiency of reduction rate in urea UN, Cr, uric acid(UA), phosphate(IP), beta-MG with RF were no less than that of hemofiltration (HF) method. The efficiency was completely dose depending on regeneration fluid volume up to 20 litter. There was no significant change in blood analysis with RF.No clinical adverse effect was recognized of patients during PIP treatment. RF system was considered to be a useful hemopurification therapy for chronic and acute renal failure and also for treatment in intensive care unit.

研制了一种新型血液净化循环过滤系统。这种新系统与传统透析一样安全，可防止透析液中的内毒素污染；不需要替代液；并可应用于血液滤过、连续血液滤过、血液滤过和连续血液滤过治疗。体外血液滤过引流液实验表明，循环液流量增加，透析单元尿素氮（UN）和肌酐（Cr）清除率增加，过滤单元β - 2-微球蛋白（β - MG）清除率增加，循环速率降低。在连续循环24小时的透析单元中，β - MG清除率未随时间显著降低。在第一个过滤器中使用牛血液和聚砜膜的体外实验中，即使使用自来水重组的透析液，也未在回收液中检测到内毒素。在血流量为210 ml/min、循环液流量为80 mVmin时，UN、Cr和β 2- MG的清除率分别为80.9 * 1.0、72.0 * 2.5和40.1* 0.9 mVmin。这些结果提示射频系统可用于维持性透析。观察RFS的临床疗效。RF法对尿素UN、Cr、尿酸（UA）、磷酸（IP）、β - mg的还原率不低于血液滤过（HF）法。效率完全取决于再生液的体积，最高可达20窝。RF血液分析无明显变化。患者在PIP治疗期间未发现临床不良反应。射频系统被认为是一种有效的血液净化治疗慢性和急性肾功能衰竭，也为治疗重症监护病房。