Extracorporeal Filtration of Thermosensitive Liposomes

热敏脂质体的体外过滤

基本信息

批准号：
10356860
负责人：
Dieter Haemmerich
金额：
$ 17.28万
依托单位：
MEDICAL UNIVERSITY OF SOUTH CAROLINA
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-03-01 至 2024-02-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10356860
关键词：
Biological Blood Blood Circulation Blood Volume Blood flow Cancerous Carotid Arteries Catheters Chest wall structure Clinical Devices Dose Dose-Limiting Doxorubicin Drug Delivery Systems Drug Monitoring Drug Targeting Electromagnetic Fields Encapsulated Excision Filtration Fluorescence Focused Ultrasound Future Goals Heart Heating Hemofiltration High Dose Chemotherapy Hour Hyperthermia In Vitro Knowledge Lasers Light Liposomes Malignant Neoplasms Malignant neoplasm of liver Malignant neoplasm of ovary Maximum Tolerated Dose Mediating Methods Modeling Monitor Organ Patients Pharmaceutical Preparations Phase Phase III Clinical Trials Public Health Rattus Recurrence Rodent Signal Transduction Stream Structure of jugular vein Technology Temperature Testing Therapeutic Time Tissues Toxic effect Translating Treatment Efficacy Tumor Volume base blood filter chemotherapy clinical practice dosage improved in vivo microwave electromagnetic radiation mortality nanoparticle nanoparticle drug novel novel strategies preclinical study prevent prototype scale up side effect targeted delivery tumor ultrasound uptake

项目摘要

PROJECT SUMMARY/ABSTRACT This project will develop a device and perform proof-of-concept studies in a rodent tumor model. The device will remove the chemotherapy agent Doxorubicin from systemic circulation after targeted delivery to tumors. Targeted delivery occurs by temperature sensitive liposomes delivering Doxorubicin to tumor regions. By exposing tumors to hyperthermia (40-42 ºC), drug is locally released and taken up by tumors at high dose. Following hyperthermia, any remaining drug would result in toxicity to non-targeted tissue, and is removed by the proposed extracorporeal filter device with real-time quantification of removed drug amount. If successful, this would represent a novel approach to reduce dose-limiting toxicities, allowing delivery of higher chemotherapy dose and/or reducing toxicity related side effects.

项目摘要/摘要该项目将开发设备并在啮齿动物肿瘤模型中进行概念验证研究。设备将靶向输送到肿瘤后，从全身循环中去除化学疗法剂阿霉素。有针对性的递送是由温度敏感脂质体传递给肿瘤区域的。经过暴露于高温（40-42ºC）的肿瘤后，药物被局部释放并被高剂量的肿瘤吸收。在热疗之后，任何剩余的药物都会导致对非靶向组织的毒性，并通过提出的具有实时量化药物量的体外过滤器设备。如果成功，这将代表一种降低剂量限制毒性的新方法，从而允许提供更高的化学疗法剂量和/或降低毒性相关的副作用。