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Extracorporeal Filtration of Thermosensitive Liposomes

热敏脂质体的体外过滤

基本信息

批准号：
10356860
负责人：
Dieter Haemmerich
金额：
$ 17.28万
依托单位：
MEDICAL UNIVERSITY OF SOUTH CAROLINA
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-03-01 至 2024-02-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10356860
关键词：
Biological Blood Blood Circulation Blood Volume Blood flow Cancerous Carotid Arteries Catheters Chest wall structure Clinical Devices Dose Dose-Limiting Doxorubicin Drug Delivery Systems Drug Monitoring Drug Targeting Electromagnetic Fields Encapsulated Excision Filtration Fluorescence Focused Ultrasound Future Goals Heart Heating Hemofiltration High Dose Chemotherapy Hour Hyperthermia In Vitro Knowledge Lasers Light Liposomes Malignant Neoplasms Malignant neoplasm of liver Malignant neoplasm of ovary Maximum Tolerated Dose Mediating Methods Modeling Monitor Organ Patients Pharmaceutical Preparations Phase Phase III Clinical Trials Public Health Rattus Recurrence Rodent Signal Transduction Stream Structure of jugular vein Technology Temperature Testing Therapeutic Time Tissues Toxic effect Translating Treatment Efficacy Tumor Volume base blood filter chemotherapy clinical practice dosage improved in vivo microwave electromagnetic radiation mortality nanoparticle nanoparticle drug novel novel strategies preclinical study prevent prototype scale up side effect targeted delivery tumor ultrasound uptake

项目摘要

PROJECT SUMMARY/ABSTRACT This project will develop a device and perform proof-of-concept studies in a rodent tumor model. The device will remove the chemotherapy agent Doxorubicin from systemic circulation after targeted delivery to tumors. Targeted delivery occurs by temperature sensitive liposomes delivering Doxorubicin to tumor regions. By exposing tumors to hyperthermia (40-42 ºC), drug is locally released and taken up by tumors at high dose. Following hyperthermia, any remaining drug would result in toxicity to non-targeted tissue, and is removed by the proposed extracorporeal filter device with real-time quantification of removed drug amount. If successful, this would represent a novel approach to reduce dose-limiting toxicities, allowing delivery of higher chemotherapy dose and/or reducing toxicity related side effects.

项目摘要/摘要该项目将开发一种装置，并在啮齿动物肿瘤模型中进行概念验证研究。该设备将靶向输送至肿瘤后，将化疗药物阿霉素从体循环中移除。靶向递送是通过将阿霉素运送到肿瘤区域的温度敏感脂质体来实现的。通过将肿瘤暴露在高温(40-42℃)中，药物在局部释放，并在高剂量下被肿瘤吸收。热疗后，任何残留的药物都会对非靶向组织产生毒性，并通过所提出的具有实时量化药物清除量的体外过滤装置。如果成功，这将是将代表一种减少剂量限制毒性的新方法，允许提供更高级别的化疗剂量和/或减少与毒性相关的副作用。