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Distribution and function of fibroblast growth factor in the retina and the epiretinal membrane.

成纤维细胞生长因子在视网膜和视网膜前膜中的分布和功能。

基本信息

批准号：
08672023
负责人：
KITAOKA Takashi
金额：
$ 1.47万
依托单位：
Nagasaki University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1996
资助国家：
日本
起止时间：
1996 至 1997
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08672023/
关键词：
Fibroblast growth factor vascular endothelial growth factor FGF VEGF FGF-5 Age-related macular degeneration subretinal vascular membrane proliferative vitreoretinopathy 網膜糖尿病網膜症

项目摘要

There are many ocular proliferative diseases such as proliferative vitreoretinopathy, agerelated macular degeneration, and proliferative diabetic retinopathy. which are major cause of adult blindness. Fibroblast growth factors (FGFs) may relate to progression of these diseases and the study of FGFs may contribute to the treatment.In the normal rat retina, acidic FGF was expressed in the retinal pigment epithelium (RPE), inner plexiform layr, and ganglion cell layr. Basic (b) FGF was expressed in the nuclei of various retinal cells. As it was reported that existence of FGF in the nucleus contributed to increase of cells, bFGF in the nucleus may ocular proliferative diseases. FGF-5 existed in the inner segment of photoreceptor cells, which suggest that FGF-5 maintain the renewal of photoreceptor outer segments. Another growth factor for ocular proliferative diseases may be vascular endothelial growth factor (VEGF). Our study reveal the expression of VEGF in the gangloin cells. VEGF may contribute to the maintenance of retinal cells.In the specimens of ARMD and PDR, and bFGF expressed in the pigment cells. On the other hand, FGF-5 expressed in the vascular endothelial cells in the ARMD vascular membrane. It may be suggested that development of subretinal vascular membrane is promoted by FGF-5. ARMD is increasing in number and anti-FGF-5 monoclonal antibody may be useful for the treatment of ARMD.

存在许多眼部增殖性疾病，例如增殖性玻璃体视网膜病变、年龄相关性黄斑变性和增殖性糖尿病视网膜病变。这是成年人失明的主要原因。成纤维细胞生长因子（fibroblastgrowthfactors，FGF）可能与这些疾病的进展有关，对FGF的研究可能有助于治疗。在正常大鼠视网膜中，酸性FGF表达于视网膜色素上皮（retinalpigmentepithelium，RPE）、内丛状层和神经节细胞层。碱性（B）FGF在各种视网膜细胞的细胞核中表达。已有研究表明，细胞核内存在的FGF有助于细胞的增殖，因此，细胞核内存在的bFGF可能与眼部增殖性疾病有关。FGF-5存在于感光细胞内节，提示FGF-5维持感光细胞外节的更新。用于眼部增殖性疾病的另一种生长因子可以是血管内皮生长因子（VEGF）。我们的研究揭示了VEGF在神经节细胞中的表达。VEGF可能参与视网膜细胞的维护，在ARMD和PDR标本中，bFGF表达于色素细胞。另一方面，FGF-5在ARMD血管膜的血管内皮细胞中表达。这可能表明FGF-5促进视网膜下血管膜的发育。ARMD的发病率呈上升趋势，抗FGF-5单克隆抗体可能对ARMD的治疗有一定作用。