THERAPY FOR MACULAR EDEMA AND RETINAL DETACHMENT BY USING WATER CHANNEL PROTEIN AQUAPORIN.

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Aquaporin (AQP) is a water channel protein which has been preserved through animals, plants, and microorganelles. In ophthalmological field, the eye and AQP have important relationship,such as that AQP exists in ciliary body, and that AQP 4 and 5 are related to the production and secretion of tear film. It was also reported that AQP 4 exists in the plasma membrane of Mueller cells. We reported that AQP exists in the internal limiting membrane which excised during vitrectomy. We discovered that AQP is more expressed in the internal limiting membrane of diabetic patient than that of non-diabetic patient. This may indicate that AQP is increasing to absorb edema or that AOP increase edema.On the other hand, it is well known that visual field defect occur after vitrectomy and we reported that hyperbaric oxygenation therapy decreased this visual field defect. This may indicate the expression of AQP is affected by oxygen. After that, we reported that the wall between vitreous pocket and Cloquet's canal may cause several diseases such as vitreo-retinal traction syndrome and retinal edema by using Triamcinolone acetonide. Finally, we used ion microscope to detect the ion and organic which showed the possibility to observe the distribution of AQP.