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The effect of hyperthermia on cervical lymph node metastasis

热疗对颈部淋巴结转移的影响

基本信息

批准号：
08672152
负责人：
HOSHINA Hideyuki
金额：
$ 1.34万
依托单位：
NIIGATA UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1996
资助国家：
日本
起止时间：
1996 至 1997
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08672152/
关键词：
Hyperthermia Metastasis Cervical lymph node metastasis RF capacitive heating system Hamster Buccal mucosa carcinoma Squamous cell carcinoma Histopathological study 頚部リンパ節転移頬粘膜癌類粘膜癌 RF誘導加温頚部リンパ節移転病理組織学

项目摘要

(1). IntroductionThis paper reports the effect of hyperthermia on cervical lymph node metastases of buccal mucosa squamous cell carcinoma O-1N in hamsters.(2). Materials and MethodsFifty golden hamsters in which O-1N was transplanted into the cheek pouch were divided into 3 groups : a heating group (21 animals) subjected to RF hyperthermia at 43ﾟC for 40 minutes twice a week, a sham group (15 animals) in which a sensor was inserted into the tumor for 40 minutes twice a week, and an untreated group (14 animals). When the tumor reached 7mm in diameter, it was heated with a 13.56MHz RF capacitive heating system. A pair of applicators each consisting of a 15-mm-diameter electrode plate was applied to the cutaneous and mucosal surfaces for heating. Intratumoral temperature was measured continuously by the C-C thermocouple thermometer. Cervical lymph nodes (LNs) and buccal tumors were removed two, three and four weeks after the experiment, respectively. LNs were histologically evaluated for the incidence of metastases and classified into a marginal-sinus metastatic type, a medullary-sinus metastatic type, an entire-node metastatic type and an extra-node metastatic type.(3). ResultsIn the heating group, incidence of metastases were reduced to 38% (8 of 21 animals) and metastases were seen within the LN capsule, whereas metastases were observed in 60% (9 of 15 animals) in the sham group and 71% (10 of 14 animals) in the untreated group and the extra-node metastatic type was found in both control groups. When the buccal tumor disappeared after heating, very few (8%) LNs metastases were found histologically, whereas matastases increased to 77.8% in the oral cancer regrowth group. Thus hyperthermia appeared to inhibit cervical LN metastasis as a result of the thermal effect on oral carcinoma.

（一）.本文报道了热疗对颊粘膜鳞癌O-1 N金黄地鼠颈淋巴结转移的影响。（二）、材料与方法将50只金仓鼠随机分为3组：加热组（21只），每周2次，每次43 ℃，每次40分钟;假手术组（15只），每周2次，每次40分钟;当肿瘤直径达到7 mm时，用13.56MHz射频电容加热系统加热肿瘤。将一对由15 mm直径电极板组成的施源器施用于皮肤和粘膜表面进行加热。采用C-C热电偶温度计连续测量瘤内温度。实验后2、3、4周分别切除颈部淋巴结和颊部肿瘤。淋巴结转移的发生率进行了组织学评估，并分为边缘窦转移型，髓窦转移型，全结转移型和结外转移型。（三）、结果热处理组转移灶发生率为38%（8/21），转移灶位于LN包膜内，假手术组转移灶发生率为60%（9/15），未处理组转移灶发生率为71%（10/14），两对照组均为淋巴结外转移灶。当颊部肿瘤在加热后消失时，在组织学上发现很少（8%）淋巴结转移，而在口腔癌再生长组中转移增加到77.8%。因此，热疗似乎抑制颈部淋巴结转移的热效应对口腔癌的结果。