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The effect of thermochemotherapy on cervical lymph node metastasis

热化疗对颈部淋巴结转移的影响

基本信息

批准号：
13672084
负责人：
HOSHINA Hideyuki
金额：
$ 0.96万
依托单位：
NIIGATA UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2001
资助国家：
日本
起止时间：
2001 至 2003
项目状态：
已结题

项目摘要

(1).IntroductionThe effect of thermochemotherapy on hamster oral squamouscell carcinomas (O-1N) were studied in their primaiy sites and in their cervical lymph node metastasis.(2).Materials and MethodsGolden hamster in which O-1N was transplanted into the cheek pouch were divided into 4 group: a hyperthermia group(HG) subjected to radiofrequency(RF) hypothermia at 43℃ for 40 minutes twice a week, a chemotherapy group(CG) in which the docetaxel was administered twice a week (10mg/kg i.p.), a thermochemotherapy group(TCG) in which docetaxel was given immediately before hyperthermia, and an untreated group(UG). When the buccal tumor reached 7mm in diameter, it was heated with a 13.56 MHz RF capacitive hyperthermia system. Intratumoral temperature was measured continuously by the C-C thermocouple thermometer. The tumor volume was calculated, primary tumor and cervical lymph nodes were excised three and four weeks after treatment, respectively, and were examined histologically.(3).ResultsThe primary tumor size was inhibited after treatment in the CG, it was decreased in the HG and TCG. Complete disappearance of tumor cells was confirmed histologically in 0 of 19 animals (0%) in the CG,3 of 16 animals (18.5%) in the HG,and 11 of 15 animals (73.3%) in the TCG. The incidence of lymph node metastasis was 42.1%(8 of 19 animals) in the CG,6.3%(1 of 16 animals) in the HG,and 13.3% (2 of 15 animals) in the TCG, compared with 88.9% (8 of 9 animals) in the UG. The histological pattern of lymph node metasitasis in the all group were confirmed within the lymph node capsule. In conclusion, the anti-tumor effect was enhanced when hyperthermia was combined with chemotherapy by docetaxel, both hyperthermia and thermochemotherapy inhibited lymph node metastasis.

研究了热化疗对仓鼠口腔鳞状细胞癌（O-1N）原发部位及颈部淋巴结转移的影响。材料与方法将O-1N移植至颊袋内的金仓鼠分为4组：热疗组（HG），采用43℃射频（RF）低温治疗40分钟，每周2次；化疗组（CG），每周2次（10mg/kg i.p）给予多西他赛；热疗组（TCG），热疗前立即给予多西他赛；当颊部肿瘤直径达到7mm时，采用13.56 MHz射频容性热疗系统进行加热。用C-C热电偶温度计连续测量瘤内温度。计算肿瘤体积，分别于治疗后3周和4周切除原发肿瘤和颈部淋巴结，并进行组织学检查(3)。结果经治疗后，大鼠组原发肿瘤大小受到抑制，大鼠组和大鼠组原发肿瘤大小减小。CG组19只动物中有0只（0%）肿瘤细胞完全消失，HG组16只动物中有3只（18.5%），TCG组15只动物中有11只（73.3%）肿瘤细胞完全消失。CG组的淋巴结转移发生率为42.1%（19只动物中8只），HG组为6.3%（16只动物中1只），TCG组为13.3%（15只动物中2只），而UG组为88.9%（9只动物中8只）。所有组淋巴结转移的组织学模式均在淋巴结囊内得到证实。综上所述，当热疗联合多西他赛化疗时，抗肿瘤作用增强，热疗和热化疗均抑制淋巴结转移。