MOLECULAR BUILDING USING N-METHYLBENZANILIDES AS A MOLECULAR SPRINT

使用 N-甲基苯甲酰苯胺作为分子冲刺的分子构建

• 批准号: 08672409
• 负责人: YAMAGUCHI Kentaro
• 金额: $ 1.15万
• 依托单位: CHIBA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08672409/
• 关键词: N-methylbenzanilide; X-ray crystallography; molecular building; molecular sprint; N-メチルベンズアミド; Nメチルベンズアミド; ベンツアニリド; ウレア; 分子副木; 結晶構造

The amide moiety has conformational and electronic characteristics which often determine the physicochemical or biological properties of a molecule, and it plays role in a variety of molecular recognition events. Most compounds having a secondary amide bond, which has a proton on the nitrogen atom, exist trans (Z) form. We found in the course of investigations on various biologically active substances that N-methylation of aromatic secondary amides or ureas causes a dramatic loss of the biological activity due to conformational change of the amide or urea structre. The importance of trans/cis stereochemistry is clear, for example in the biochemistry of immunosuppressants.Conformation of benzanilide, N-methylbenzanilide and those with a methyl group (s) ortho to the amide bond in solution and in the crystal have been studied. N-Methylbenzanilide exists in cis-amide (E) form in the crystal. In CDCl_3 solution, cis-amide form is also predominant (99%), whele benzanilide exists in trans-am … More ide (Z) form in the crystal and in solution. In the crystal, all the methyl-substituted benzanilides exists in trans-amide conformation and the introduction of an ortho-methyl group (s) makes the interplanar angle of the aromatic rings and the amide group (Ar-amide) larger. N-Methylbenzanilides exist in cis form in the crystal except the compound (26) which has four methyl groups ortho to the amide bond. For the N-methylbenzanilides, the effects of introduction of one or two ortho-methyl group on the dihedral angles of Ar-amide are smaller than that of the secondary benzanilides. In solution, benzanilides exist exclusively in trans conformation except for the compound (12) which has a minor cis conformer (3%) in CDDl_3, whereas N-methylbenzanilides exist in equilibrium between the major cis-form and the minortrans-from. The tetramethyl derivative exists in trans conformation in solution as observed in the crystal. For, N-metylbenzanilides, an introduction of a methyl group (s) ortho to the amide bond seems to destabilize the cis-amide conformation in solution, resulting in an increased ratio of the trans-amide conformation. Less

酰胺部分具有构象和电子特征，这些特征通常决定分子的物理化学或生物学性质，并且它在各种分子识别事件中起作用。大多数具有仲酰胺键的化合物，其在氮原子上具有质子，存在反式（Z）形式。我们在对各种生物活性物质的研究过程中发现，芳香族仲酰胺或脲的N-甲基化由于酰胺或脲结构的构象变化而导致生物活性的急剧损失。反式/顺式立体化学的重要性是显而易见的，例如在免疫抑制剂的生物化学中。已经研究了苯甲酰苯胺、N-甲基苯甲酰苯胺和在酰胺键邻位具有甲基的那些苯甲酰苯胺在溶液和晶体中的构象。N-甲基苯甲酰苯胺在晶体中以顺式酰胺（E）形式存在。在CDCl_3溶液中，顺式酰胺形式也占优势（99%），而苯甲酰苯胺则以反式酰胺形式存在 ...更多信息 在晶体中和溶液中均形成了化合物（Z）。在晶体中，所有甲基取代的苯甲酰苯胺都以反式酰胺构象存在，并且邻位甲基的引入使得芳环和酰胺基团（Ar-amide）的面间角更大。N-甲基苯甲酰苯胺在晶体中以顺式形式存在，除了化合物（26）在酰胺键邻位有四个甲基。对于N-甲基苯甲酰苯胺，引入一个或两个邻位甲基对芳酰胺二面角的影响小于仲苯甲酰苯胺。在溶液中，除了化合物（12）在CDD1_3中具有少量顺式构象（3%）之外，苯甲酰苯胺仅以反式构象存在，而N-甲基苯甲酰苯胺以主要顺式构象和少量反式构象之间的平衡存在。在晶体中观察到，四甲基衍生物在溶液中以反式构象存在。对于N-甲基苯甲酰苯胺，在酰胺键邻位引入甲基似乎使溶液中的顺式酰胺构象不稳定，导致反式酰胺构象的比例增加。少

项目成果

A.Tanatani: "Hellical Arowatic Vrea and Guanidine" Tetrahedron Lett.4425-4428 (1997)

A.Tanatani：“地狱 Arowatic Vrea 和胍”四面体 Lett.4425-4428 (1997)

K.Yamaguchi: "Disodium Fluoresein Octahydral" Acta Crystallogr. C53. 284-285 (1997)

K.Yamaguchi：“八水氟树脂二钠”Acta Crystallogr。

K.Yamaguchi, Z.Tamura, M.Maeda: "Disodium Fluoresein Octahedral" Acta Crystallogr.C53. 284-285 (1997)

K.Yamaguchi、Z.Tamura、M.Maeda：“氟树脂八面体二钠”Acta Crystallogr.C53。

K.Yamaguchi, Z.Tamura, M.Maeda: "Molecular Structure of the Zwitterionic Form of Phenolsulfonphthalein" Analytical Science. 13. 521-522 (1997)

K.Yamaguchi、Z.Tamura、M.Maeda：“酚磺酞两性离子形式的分子结构”分析科学。

K.Yamaguchi: "Molecular Sturucture of the Zwitterionic Form of Pherolsulforphthalein" Analytical Science. 13. 521-522 (1997)

K.Yamaguchi：“酚磺酞两性离子形式的分子结构”分析科学。