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CHEMICAL SCREENING AND OPTIMIZATION FACILITY - PROTEIN EXPRESSION AND/OR X-RAY CRYSTALLOGRAPHY

化学筛选和优化设施 - 蛋白质表达和/或 X 射线晶体学

基本信息

批准号：
10942884
负责人：
LEYI GONG
金额：
$ 26.12万
依托单位：
SRI INTERNATIONAL
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-29 至 2026-09-27
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10942884
关键词：
Adenomyosis Bacterial Infections Chemicals Contraceptive Agents Contraceptive methods Contracts Crystallization Data Development Down Syndrome Dysmenorrhea Fetal Growth Retardation Fibroid Tumor Generations Gestational Diabetes Gynecologic Health Infertility Inflammation Lactation Muscular Dystrophies National Institute of Child Health and Human Development Necrotizing Enterocolitis Pelvic Pain Peptides Performance Perinatal Pituitary-dependent Cushing&apos s disease Placenta Polycystic Ovary Syndrome Pre-Eclampsia Premature Birth Production Proteins Recombinant Proteins Reproductive Health Research Resolution Rett Syndrome Role Sampling Sepsis Structure United States National Institutes of Health Virus Diseases Vulvodynia Work X-Ray Crystallography autism spectrum disorder endometriosis improved inhibitor interest mastitis microbiome protein expression protein purification screening small molecule

项目摘要

The Chemical Screening and Optimization Facility (CSOF) fulfills a unique role by identifying, optimizing and conducting production identified small molecules for contraceptive and reproductive health related (e.g., infertility, polycystic ovarian syndrome, fibroids, endometriosis, dysmenorrhea, adenomyosis, gynecologic and/or pelvic pain, and vulvodynia, premature birth, placenta health, improving lactation quality and quantity, preeclampsia, perinatal microbiome, gestational diabetes, inflammation, bacterial infections, viral infections, necrotizing enterocolitis, bronchopulmonary dyplasia, pre-term birth, fetal growth restriction, mastitis, Cushing's disease, Down Syndrome, Ricketts, Muscular Dystrophy, Rett syndrome, sepsis, or Autism) research. One approach is to perform x-ray crystallography studies with active target proteins or peptides in the presence or absence of chemical entities of interest. The research contained within this task order will encompass generation and purification of proteins or peptides of interest, development of crystals, and structural analysis by x-ray crystallography.

化学筛选和优化设施（CSOF）通过鉴定、优化和进行生产鉴定的用于避孕和生殖健康相关的小分子（例如，不孕症、多囊卵巢综合征、纤维瘤、子宫内膜异位症、痛经、子宫腺肌病、妇科和/或盆腔疼痛和外阴痛、早产、胎盘健康、改善泌乳质量和数量、先兆子痫、围产期微生物组、妊娠糖尿病、炎症、细菌感染、病毒感染、坏死性小肠结肠炎、支气管肺发育不良、早产、胎儿生长受限、乳腺炎、库欣病，唐氏综合征、里基茨综合征、肌营养不良、雷特综合征、败血症或自闭症）研究。一种方法是在存在或不存在感兴趣的化学实体的情况下用活性靶蛋白或肽进行X射线晶体学研究。该任务订单中包含的研究将包括感兴趣的蛋白质或肽的生成和纯化，晶体的开发以及X射线晶体学的结构分析。