CHEMICAL SCREENING AND OPTIMIZATION FACILITY - PROTEIN EXPRESSION AND/OR X-RAY CRYSTALLOGRAPHY

化学筛选和优化设施(CSOF)通过识别、优化和进行与避孕和生殖健康相关的小分子研究(例如：不孕症、多囊卵巢综合征、子宫肌瘤、子宫内膜异位症、痛经、子宫腺肌症、妇科和/或盆腔疼痛、外阴疼痛、早产、胎盘健康、提高哺乳质量和数量、先兆子痫、围产期微生物群、妊娠期糖尿病、炎症、细菌感染、病毒感染、坏死性小肠结肠炎、支气管肺发育不良、早产、胎儿生长受限、乳腺炎、库兴氏病、唐氏综合症、立克病、肌肉萎缩、Rett综合征、败血症或自闭症)来发挥独特的作用。一种方法是在存在或不存在感兴趣的化学实体的情况下，对具有活性的目标蛋白质或多肽进行X射线结晶学研究。这项任务中包含的研究将包括产生和提纯感兴趣的蛋白质或多肽，开发晶体，以及用X射线结晶学进行结构分析。

The Chemical Screening and Optimization Facility (CSOF) fulfills a unique role by identifying, optimizing and conducting production identified small molecules for contraceptive and reproductive health related (e.g., infertility, polycystic ovarian syndrome, fibroids, endometriosis, dysmenorrhea, adenomyosis, gynecologic and/or pelvic pain, and vulvodynia, premature birth, placenta health, improving lactation quality and quantity, preeclampsia, perinatal microbiome, gestational diabetes, inflammation, bacterial infections, viral infections, necrotizing enterocolitis, bronchopulmonary dyplasia, pre-term birth, fetal growth restriction, mastitis, Cushing's disease, Down Syndrome, Ricketts, Muscular Dystrophy, Rett syndrome, sepsis, or Autism) research. One approach is to perform x-ray crystallography studies with active target proteins or peptides in the presence or absence of chemical entities of interest. The research contained within this task order will encompass generation and purification of proteins or peptides of interest, development of crystals, and structural analysis by x-ray crystallography.